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EC number: 210-868-4 | CAS number: 624-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl methyl sulphide
- EC Number:
- 210-868-4
- EC Name:
- Ethyl methyl sulphide
- Cas Number:
- 624-89-5
- Molecular formula:
- C3H8S
- IUPAC Name:
- (methylsulfanyl)ethane
- Details on test material:
- METHYL ETHYL SULFIDE, Code: 1992,
Source: Pennwalt Corporation
Lot: T 28.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Albino rats, Spraque-Dawley. One control group and 1 test group each of 5 male and 5 female rats.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- By inhalation of a test atmosphere containing vapour of the test substance.
4 hours continuous whole-body exposure. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas cromatography
- Duration of exposure:
- 4 h
- Concentrations:
- 21.72 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- 14 days post exposure
- Statistics:
- Not appropriate
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 21.72 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study
- Clinical signs:
- other: (a) During exposure: No abnormalities. (b) During the observation period: No abnormalities
- Body weight:
- Slight loss of bodyweight or reduction of rate of bodyweight gain for one day following exposure.
- Gross pathology:
- Macroscopic pathology: Dark areas on lungs of 1 female rat exposed to METHYL ETHYL SULFIDE.
- Other findings:
- Food and water consumption: Food consumption was slightly reduced for 1 day following exposure. Possible slight elevation of water consumption for a few days following exposure in female rats only.
Lung weight to body weight ratio: The lung weight to body weight ratio for female rats exposed to METHYL ETHYL SULFIDE was higher than the control values. Males were unaffected.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and GHS
- Conclusions:
- The 4h-LC0 in higher than 21.72 mg/l in both male and female rats
- Executive summary:
In an acute inhalation toxicity study performed according to the OECD guideline # 403 and GLP, no mortality and clinical sign of toxicity was observed in male and female rats exposed to an atmosphere concentration of 21.72 mg/l (6988 ppm) of methyl ethyl sulfide for 4 hours. At necropsy, dark areas was observed on lungs of 1 female rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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