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Diss Factsheets
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EC number: 210-539-5 | CAS number: 617-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary references
Data source
Materials and methods
- Type of study:
- other: human maximization study
- Justification for non-LLNA method:
- before adoption of LLNA method
In vivo test system
Test animals
- Species:
- other: human
Results and discussion
Any other information on results incl. tables
Sensitization |
Data lacking No valid studies are available. The available study gets a K4 since no original references are available only secondary references.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria
Classification and Labeling Since only secondary references are available the data is not sufficient for C&L purposes. |
A maximization test was carried out on 25 volunteers. The material (RIFM no. 76-331) was tested at a concentration of 4% in petrolatum and produced no sensitization reactions.
In a human maximization study involving 25 subjects, there were no positive reactions to (2760 µg/cm2) in petrolatum. The patch site was pre-treated for 24-h with 2.5% aqueous sodium lauryl sulfate under occlusion. Test material was then applied under occlusion to the same site on the volar forearm or back for a total of five alternate-day 48 h periods. Following a 10-day rest period, fresh challenge sites were pretreated for 1 h with 5–10% aqueous sodium lauryl sulfate solution and challenge patches were then applied to fresh sites under occlusion for 48 h. Challenge sites were evaluated immediately after patch removal and at 24 h |
Kligman. A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. Invest. Derm..47, 393; Kligman. A. M. (1977). Report to RIFM. 6 June; Kligman. A. M. & Epstein. W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis1, 231. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982
RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Report on Human Maximization Studies. RIFM Report No. 1702, June 06. RIFM, Woodcliff Lake, NJ, USA. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
Repeated Insult Patch Test: Fifty-five human subjects received 24-hr exposures to test patches three times weekly for 3 weeks and a challenge patch in the sixth week. There was little or no primary irritation. There was, however, a definite indication of skin sensitization in 7 of the 35 subjects, and more or less equivocal evidence of sensitization in 10 other subjects. |
HERCULES INC; Technical Data Bulletin for Di-Cup (Dicumyl Peroxide) Including Toxicity Data for A-Methylstyrene, One of its Decomposition Products; 00/00/00; EPA No. 86-870001667; Fiche No. OTS0515743 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No valid studies are available. The available study gets a K4 since no original references are available only secondary references.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria
- Executive summary:
No valid studies are available. The available study gets a K4 since no original references are available only secondary references.The lack of individual scores and the use of a non-standard technique preclude classification on the basis of EU or GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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