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Diss Factsheets
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EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
For the purposes of the registration of K2TaF7, under REACH, a justification for the omission of in vivo studies is presented in Section 13 (Assessment Reports). This document provides a waiver for the conduct of in vivo studies with K2TaF7, and proposes a basis and rationale for the Human Health risk assessment, other than through the establishment of DNELs.
Aqueous solutions of K2TaF7 at physiological temperatures yield the complex ion TaF72- , a Lewis acid which imparts a pH of 2 to the solution, which is capable of causing serious damage to eyes (when K2TaF7 is introduced into rabbit eyes). In gastric juice (0.1 N HCl) the presence of hydrochloric acid promotes the degradation of K2TaF7 to Ta2O5, KF and HF. Ta2O5, is biologically inert and considered toxicologically not relevant for Human health risk assessment purposes in this scenario. KF and HF are considered responsible for acute corrosive portal-of-entry effects seen in the GIT in rats gavaged with K2TaF7. The effects after repeat dosing in a range finding study showed effects that were reasonably attributable to liberated fluoride, such that all further in vivo testing could be waived on the basis of corrosivity. At sub-corrosive concentrations in vivo, the fluoride ion remains toxicologically relevant and exposure to the fluoride ion from occupational exposures to K2TaF7 should be considered against the European upper tolerable intake level for fluoride.
Short description of key information:
No study conducted.
Effects on developmental toxicity
Description of key information
No study conducted.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
For the purposes of the registration of K2TaF7, under REACH, a justification for the omission of in vivo studies is presented in Section 13 (Assessment Reports). This document provides a waiver for the conduct of in vivo studies with K2TaF7, and proposes a basis and rationale for the Human Health risk assessment, other than through the establishment of DNELs.
Aqueous solutions of K2TaF7 at physiological temperatures yield the complex ion TaF72- , a Lewis acid which imparts a pH of 2 to the solution, which is capable of causing serious damage to eyes (when K2TaF7 is introduced into rabbit eyes). In gastric juice (0.1 N HCl) the presence of hydrochloric acid promotes the degradation of K2TaF7 to Ta2O5, KF and HF. Ta2O5, is biologically inert and considered toxicologically not relevant for Human health risk assessment purposes in this scenario. KF and HF are considered responsible for acute corrosive portal-of-entry effects seen in the GIT in rats gavaged with K2TaF7. The effects after repeat dosing in a range finding study showed effects that were reasonably attributable to liberated fluoride, such that all further in vivo testing could be waived on the basis of corrosivity. At sub-corrosive concentrations in vivo, the fluoride ion remains toxicologically relevant and exposure to the fluoride ion from occupational exposures to K2TaF7 should be considered against the European upper tolerable intake level for fluoride.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation 1272/2008, the test material does not require classification for reproductive or developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.