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EC number: 254-959-7 | CAS number: 40530-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 May 2018 - 18 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- Identification: FAT 93503/B TE
Chemical name: Carbonic acid, 2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenyl)oxy]ethyl-ethyl-ester
CAS number: 40530-60-7
Appearance/Physical state: Red powder
Batch: 20131219 (China)
Purity: 100.3 % w/w (total organic constituents)
Expiry date: 20 January 2019
Storage conditions: Room temperature in the dark - Radiolabelling:
- not specified
- Details on study design: HPLC method:
- HPLC System: Agilent Technologies 1100 Series
Detector type: variable wavelength (VW)
Column: XSelect HSS Cyano 5µm (150 x 4.6 mm id)
Column temperature: 30 °C
Mobile phase: Methanol: purified water (55:45 v/v)
pH of mobile phase: 5.6
Flow-rate: 1.0 mL/min
Injection volume: 10 µL
VW detector wavelength: 210 nm (standards and dead time); 254 nm (sample)
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity* 99.6%) of a 757 mg/L solution in methanol: purified water (50:50 v/v). - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 4.83 dimensionless
- pH:
- 7
- Remarks on result:
- other: Rest of information not provided
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- ca. 66 800 dimensionless
- pH:
- 7
- Remarks on result:
- other: Rest of information not provided
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
- Details of fitted regression line (log k' vs. log Koc): first order correlation - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of FAT 93503/B has been determined to be 66800, (log10 Koc = 4.83).
- Executive summary:
The adsorption coefficient for FAT 93503/B was determined by the HPLC screening method, using a procedure designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. As the test item has predicted dissociation constants of 9.2 (acid) and 3.2 (base) and therefore will be in a non-ionized form in the environmentally relevant range of 5.5 to 8.5. Therefore testing was performed at neutral pH with the test item in the non-ionized form. The slope of the calibration curve for the reference standards showed good first order correlation and the retention times between duplicate injections for each solution were consistent, the HPLC method was considered valid for the determination of adsorption coefficient. Based on the chromatographic data, the test item was considered to be stable during the test procedure. Based on the findings of the study, the adsorption coefficient of the test item has been determined to be 66800, log10 Koc 4.83. The results classify the test item as immobile.
Reference
Description of key information
The adsorption coefficient for FAT 93503/B was determined by the HPLC screening method, using a procedure designed to be compatible with EU Method C.19 and OECD Guideline 121. The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The test item has predicted dissociation constants of 9.2 (acid) and 3.2 (base) and therefore will be exisiting in a non-ionized form in the environmentally relevant range of pH 5.5 to 8.5. Therefore, testing was performed at neutral pH with the test item in the non-ionized form. The slope of the calibration curve for the reference standards showed good first order correlation and the retention times between duplicate injections for each solution were consistent, the HPLC method was considered valid for the determination of adsorption coefficient. Based on the chromatographic data, the test item was considered to be stable during the test procedure. Based on the findings of the study, the adsorption coefficient of the test item has been determined to be 66800, log10 Koc 4.83. The results classify the test item as immobile.
Key value for chemical safety assessment
- Koc at 20 °C:
- 66 800
Additional information
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