Registration Dossier
Registration Dossier
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EC number: 700-651-7 | CAS number: 692-49-9
Endpoint summary
Administrative data
Description of key information
No dedicated studies are available for the evaluation of skin, eye, or respiratory tract irritation potential of the substance. However, during acute and repeated dose inhalation exposures with the substance, no signs of skin, eye, or respiratory irritation were observed. These studies include nose-only exposures for 4 hours in rats up to 102900 ppm (690413 mg/m3), whole-body exposures for 2 hours in rats up to 21000 ppm (140902 mg/m3), whole-body repeat exposures in rats and rabbits to concentrations as high as 50000 ppm (335480 mg/m3) and 15000 ppm (10064 mg/m3), respectively.
Key value for chemical safety assessment
Additional information
Irritation studies are technically not feasible because the substance volatilizes at biological temperatures and ambient pressure. However no signs of eye, skin, or respiratory irritation were observed in several inhalation toxicity studies. These studies include nose-only exposures for 4 hours in rats up to 102900 ppm (690413 mg/m3), whole-body exposures for 2 hours in rats up to 21000 ppm (140902 mg/m3), whole-body repeat exposures in rats and rabbits to concentrations as high as 50000 ppm (335480 mg/m3) and 15000 ppm (10064 mg/m3), respectively. Therefore, no classification is required for skin or eye irritation according to EU Directive 67/548/EEC and the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
