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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-02-04 to 2004-02-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Version / remarks:
2001
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Radiolabelling:
no
Test temperature:
25 °C
Details on study design: HPLC method:
The chromatographic conditions were the same for the determination of t0, the establishment of the calibration graph and the measurement of the test item.

HPLC equipment: HPLC pump G1312A, autosampler G1313A, column oven G1316A, degaser G1322A and Diode Array Detector G1315B by Agilent;

Stationary phase: LiChrospher 100 CN 5pm by Duratec (18704-02); material: stainless steel, dimensions: 125 mm x4.6 mm column temperature: 25 °C

Mobile Phase: 400 mL acetonitrile + 1600 mL cleaned water, isocratic elution

Flow rate: 1.0 mL/min
Injection volume: 10 µL
Detection wavelength 210 nm
Injection amounts: Dead time marker: 22.5 µg; Calibration substances: 0.72 - 2.24 µg; Test item: 0.70 µg

The dead time marker and the calibration substances were dissolved in acetonitrile and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. The item was dissolved and diluted 0.1 to 1 in the mobile phase and injected as single solution twice.
Key result
Type:
log Koc
Value:
1.7
Temp.:
25 °C
Details on results (HPLC method):
- Retention times of reference substances used for calibration:
Acetanilline: 3.08 min
Benzamide: 2.54 min
Phenole: 3.00 min
Atrazin: 4.71 min
Monuron: 4.86 min
Triadimenol: 9.66 min
Linuron: 10.19 min
Naphthalene: 10.73 min

- Average retention data for test substance: 3.97
Validity criteria fulfilled:
yes
Conclusions:
The adsorption coefficient of the test item was determined to be logKoc = 1.7 applying the HPLC-method described in the OECD TG 121.
Executive summary:

The adsorption/desorption coefficient KOC of the test item was assessed according to OECD TG 121 applying the HPLC method. As a result the logKOC of 1.7 was determined.

Description of key information

According to an OECD TG 121 compliant study, the adsorption/desorption coefficient of the test item was determined to be logKoc = 1.72 at 25 °C (reference 5.4.2-1).

Key value for chemical safety assessment

Additional information

According to an OECD TG 121 compliant study, the adsorption/desorption coefficient of the test item was determined to be logKoc = 1.72 at 25 °C.