Registration Dossier
Registration Dossier
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EC number: 459-270-7 | CAS number: 2568-33-4 MBD
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No TK study performed only data available from individual toxicity testing summarised.
MBD has a low molecular weight but is highly soluble in water and is therefore unlikely to be passively absorbed
across a lipid based membrane. It has a low partition coefficient which indicates it is unlikely to bioaccumulate.
Absorption
There was no evidence of absorption from the acute oral or dermal toxicity studies. On the 28-day oral toxicity study
the minor effects of APPT, albumin and male adrenal and thymus weights provided some evidence of absorption.
Distribution
The haematology, blood chemistry and organ weight disturbances metioned above provides evidence of general
systemic distribution. There was not evidence of distribution to the central nervous system.
Metabolism
The various studies performed did not provide any information with respect to metabolism.
Excretion
The various studies performed did not provide any information with respect to excretion.
Bioaccumulation
There was no evidence of bioaccumulation.
Conclusion
There was limited evidence of absorption via the oral route after repeated administration resulting in the general
systemic distribution. There was no evidence of distribution to the central nervous system nor evidence of metabolism,
excretion or bioaccumulation.
Key value for chemical safety assessment
Additional information
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