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Diss Factsheets
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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
'Benzene, ethylenated by-products' was tested in a standard OECD guideline mouse LLNA. At the mid and high doses (50 and 100%) there was an increase in the stimulation index compared to control that exceeded 3x indicating that this substance was capable of inducing proliferation of the lymph nodes at these concentrations. The EC3 value of 30.3% was calculated indicating that this is possibly a very weak sensitiser. In the mid and high dose groups there was also evidence of swelling of the ears relative to control and this is consistent with the irritancy of the test material. It is possible that the result of the local lymph node assay is due to a non-specific induction of lymphnode proliferation rather than a specific sensitising response to this substance. This could be due in part to the irritancy of the material. In the entire history of use of this material there have been no reports of workers becoming sensitised to this substance through dermal exposure. Therefore, whilst this substance may be technically capable of inducing lymphnode cell proliferation in the LLNA, the relevance of that result to humans may be limited.
Migrated from Short description of key information:
Mouse LLNA assay
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no data or indication from humans that this substance is a respiratory sensitiser
Migrated from Short description of key information:
No data available
Justification for classification or non-classification
Due to the classification criteria set out in the CLP being limited to the classification as either a sensitiser or not a sensitiser, this substance must be classified as a sensitiser based solely on the positive result in the LLNA. However the EC3 value of >30% indicates that it is a weak sensitiser and so the risk to humans is relatively small. It is also possible that the irritancy of the material and its solvent activity could have produced a non-specific proliferation response in the lymph nodes, but without additional information it is not possible to make a firm judgment. Therefore this substance should be classified as a (weak) sensitiser, Category 1B according to CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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