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EC number: 239-364-2 | CAS number: 15336-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral LD50 of ammonium hexachlororhodate (III) was established to be 1844 and 2571 mg/kg bw in male and female rats, respectively. An LD50 of 2182 mg/kg bw was calculated on analysis of the data for both sexes together (Dreher, 1989).
No relevant acute dermal or inhalation toxicity data were identified, or are required at this tonnage.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 September-12 October 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Bantin & Kingman Ltd., Grimston, Aldborough, Hull, U.K.
- Age at study initiation: Main study: Approximately 5-8 weeks old
- Weight at study initiation: Main Study: Males, 122-173 g; Females, 120-173 g
- Fasting period before study: overnight
- Housing: In groups of up to five by sex in solid-floor polypropylene cages with sawdust bedding.
- Diet (e.g. ad libitum): Ad libitum Rat and Mouse expanded diet No. 1, Special Diet Services Limited, Witham, Essex, U.K.
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Minimum of five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-24ºC
- Humidity (%): 54-64%
- Air changes (per hr): Approximately 15 changes/hr
- Photoperiod (hrs dark / hrs light): 12 hrs darkness/12 hrs light
IN-LIFE DATES: From: To:- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
VEHICLE
- Concentration in vehicle:Main study: 100, 144.2, 208, 300 mg/ml
- Amount of vehicle (if gavage):Main study: 10 ml/kg bw
- Justification for choice of vehicle: no data
- Lot/batch no. (if required):
- Purity:
MAXIMUM DOSE VOLUME APPLIED:Main study 10 ml/kg bw
DOSAGE PREPARATION (if unusual):- Doses:
- Range-finding study: 500, 1000, 3000, or 5000 mg/kg bw
Main study: 1000, 1442, 2080 or 3000 mg/kg bw - No. of animals per sex per dose:
- Range-finding study: One rat/sex/dose
Main study: Five rats/sex/dose - Control animals:
- no
- Details on study design:
- Duration of observation period following administration: Main study:14 days (range-finding study: 5 days)
- Frequency of observations and weighing: Main study: animals observed 1 and 4 hrs after dosing and subsequently once daily for 14 days. Individual bodyweights were recorded on day of treatment (day 0), days 7 and 14, or at death (range-finding study: animals were observed at 1 and 4 hrs and then daily for 5 days; weighed before dosing).
- Necropsy of survivors performed: yes
- Other examinations performed: none- Statistics:
- Probit analysis (Finney, 1971)
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 182 mg/kg bw
- 95% CL:
- 1 814 - 3 211
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 844 mg/kg bw
- 95% CL:
- 1 509 - 2 254
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 571 mg/kg bw
- 95% CL:
- 1 553 - 4 256
- Mortality:
- In the range-finding study, both rats died on the day of treatment in the 3000 and 5000 mg/kg bw dose level groups. No deaths were observed in the 500 and 1000 mg/kg bw dose level groups over the five-day observation period.
In the main study, no deaths were observed, over the 14-day observation period, in groups of five animals/sex treated at 1000 mg/kg bw. Deaths were noted at between 4 hrs and two days after treatment at the higher tested dose levels. One male and one female died in the 1442 mg/kg bw treatment groups. Three males and two females died after treatment with the 2080 mg/kg bw dose level. All five males and three females died at the high dose level of 3000 mg/kg bw. - Clinical signs:
- In the main study, signs of toxicity were noted in all dose groups and included hunched posture and pilo-erection. In addition, lethargy and ataxia were seen in the animals in the 2080 and 3000 mg/kg bw dose groups. At the highest tested dose of 3000 mg/kg bw, decreased respiratory rate and ptosis were also seen. Surviving animals appeared normal two days after treatment.
- Body weight:
- Data for individual bodyweights and weekly bodyweight gains are tabulated. The authors do not comment on the presented data.
- Gross pathology:
- Gross necropsy of animals that died during the study revealed abnormally red lungs, dark liver and haemorrhage of the glandular gastric epithelium. Haemorrhage of the small intestine was also noted in one male from the 3000 mg/kg bw treatment group. No abnormalities were seen at necropsy of the animals that survived during the 14-day observation period.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of ammonium hexachlororhodate (III) was established to be 1844 and 2571 mg/kg bw in male and female rats, respectively. An LD50 of 2182 mg/kg bw was calculated on analysis of the data for both sexes together.
- Executive summary:
The acute oral toxicity of ammonium hexachlororhodate (III) was investigated in an OECD Test Guideline 401 study, conducted according to GLP. The test substance was administered by oral stomach tube to Sprague-Dawley rats (5/sex/dose) at 1000, 1442, 2080 or 3000 mg/kg bw, based on the results of a range-finding study, and animals were observed for 14 days.
No mortality was observed at the lowest dose and a single male and female died at 1442 mg/kg bw. Three males and two females died at 2080 mg/kg bw, while all animals died at the top dose. Signs of toxicity were noted in all dose groups and included hunched posture and pilo-erection. In addition, lethargy and ataxia were seen in the animals in the 2080 and 3000 mg/kg bw dose groups. At the highest tested dose of 3000 mg/kg bw, decreased respiratory rate and ptosis were also seen. Surviving animals appeared normal two days after treatment. Gross necropsy of animals that died during the study revealed abnormally red lungs, dark liver and haemorrhage of the glandular gastric epithelium. Haemorrhage of the small intestine was also noted in one male from the 3000 mg/kg bw treatment group. No abnormalities were seen at necropsy of the animals that survived during the 14-day observation period.
Using the probit method, the acute oral LD50 for ammonium hexachlororhodate (III) was calculated to be 2571 (1553-4256, 95% confidence limit) mg/kg bw in female rats and 1844 (1509-2254, 95% confidence limit) mg/kg bw in males. An LD50 of 2182 (1814-3211, 95% confidence limit) mg/kg bw was calculated on analysis of the data for both sexes together. The study authors do not comment on the potentially greater sensitivity to the test substance shown by the male animals.
Based on the results of this study, no classification is required for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 182 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
The acute oral toxicity of ammonium hexachlororhodate (III) was investigated in an OECD Test Guideline 401 study, conducted according to GLP. The test substance was administered by oral stomach tube to Sprague-Dawley rats (5/sex/dose) at 1000, 1442, 2080 or 3000 mg/kg bw, based on the results of a range-finding study, and animals were observed for 14 days. No mortality was observed at the lowest dose and a single male and female died at 1442 mg/kg bw. Three males and two females died at 2080 mg/kg bw, while all animals died at the top dose. Signs of toxicity were noted in all dose groups and included hunched posture and pilo-erection. In addition, lethargy and ataxia were seen in the animals in the 2080 and 3000 mg/kg bw dose groups. At the highest tested dose of 3000 mg/kg bw, decreased respiratory rate and ptosis were also seen. Surviving animals appeared normal two days after treatment. Gross necropsy of animals that died during the study revealed abnormally red lungs, dark liver and haemorrhage of the glandular gastric epithelium. Haemorrhage of the small intestine was also noted in one male from the 3000 mg/kg bw treatment group. No abnormalities were seen at necropsy of the animals that survived during the 14-day observation period. Using the probit method, the acute oral LD50 for ammonium hexachlororhodate (III) was calculated to be 2571 mg/kg bw in female rats and 1844 mg/kg bw in males. An LD50 of 2182 mg/kg bw was calculated on analysis of the data for both sexes together. The study authors did not comment on the potentially greater sensitivity to the test substance shown by the male animals (Dreher, 1989).
No acute dermal or inhalation toxicity data were identified, or are required at this tonnage (1-10 tpa).
Justification for selection of acute toxicity – oral endpoint
OECD guideline study, and the only acute oral toxicity study available.
Justification for classification or non-classification
Based on the results of the available and reliable acute oral study in rats, triammonium hexachlororhodate does not require classification for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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