Registration Dossier
Registration Dossier
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EC number: 215-170-3 | CAS number: 1309-42-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Test not necessary.
Key value for chemical safety assessment
Additional information
Magnesium hydroxide has a very low solubility in water (1.78 x 10^-3 g total solids/L) and any Magnesium hydroxide dissolved is dissociated completely. Magnesium hydroxide will not bioaccumulate or adsorb to sediment based on the derived Kd value of 1.65 and the toxioctinetics of the substance (see section 7.1 for details). In short, the oral absorption of magnesium hydroxide for risk assessment purposes is set at 50%. Magnesium hydroxide has characteristics favorable for fast urinary excretion: low molecular weight (below 300), reasonable water solubility, and ionization of the molecule at the pH of urine. Urinary magnesium excretion is very rapid in humans with normal renal function, the magnesium clearance increasing as a roughly linear function of the serum magnesium concentration.
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