Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 431-060-1 | CAS number: 153719-38-1
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Effects of the test item CA 2343A, an intermediate of CGA 293343 on adult earthworms, which were placed in a defined substrate containing the test item, were examined. Mortality of earthworms was recorded after 7 and 14 days. In addition, the weight of surviving worms was determined at day 0 and at day 14 and weight alterations of treated worms were compared to untreated controls.
Based on the results of a preliminary range-finding test at a concentration range of 1 to 1000 mg/kg dry weight of soil (causing no mortality) the definitive test was performed as a limit test at a concentration of 1000 mg/kg dry soil in comparison with the untreated control. After 14 days exposure, no mortality was recorded in the test item group or control group. After the evaluation of the results and after a statistical analysis (computer program EASY ASSAY Multiple Testing), a significant difference regarding the body weight compared to the control was calculated. No other sublethal symptoms were observed at 1000 mg/kg dry weight of soil, such as increased burrowing time or flaccidity.
The sensitivity of the test system was demonstrated with the reference item 2-chloroacetamide which was tested at concentrations of 11, 14, 18, 24 and 31 mg/kg dry weight of soil. In the most recent test with the reference item, dated 27.03.01, the LC50was calculated at 19.2 mg/kg dry weight of soil.
Founded on these results no negative effects on worm survival could be demonstrated. Hence the highest concentration with no lethal symptoms observed was 1000mg/kg dry weight of soil (i.e. the highest rate tested) and the LC50of CA 2343 A to Eisenia fetida could not be determined after 14 days exposure but is clearly shown to be greater than 1000 mg/kg artificial soil.
Concerning the living weight/worm there was a reduction of 30.6% in the 1000 mg/kg d.w. treatment of CA 2343A over 14 days. This reduction was statistically significant from the control weight reduction of 9.3% over the same period.
V...
Key value for chemical safety assessment
Additional information
Guideline Test Type |
Species |
LC50(14 days) |
Reference |
Reliability
|
OECD 207 |
Eisenia fetida |
Could not be determined; clearly > 1000 mg/kg dry weight of soil |
Friedrich, S., Syngenta, 2001 |
Reliable without restrictions |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
