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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented peer reviewed study
Data source
Reference
- Reference Type:
- publication
- Title:
- Reproductive toxicity evaluation of vanadium in male mice
- Author:
- Llobet JM, Colomina MT, Sirvent JJ, Domingo JL & Corbella J
- Year:
- 1 993
- Bibliographic source:
- Toxicology. 80(2-3): 199-206, 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of the effects of vanadium on male fertility
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Sodium metavanadate
- EC Number:
- 237-272-7
- EC Name:
- Sodium metavanadate
- Cas Number:
- 13718-26-8
- IUPAC Name:
- Sodium metavanadate
- Details on test material:
- - Name of test material (as cited in study report): Sodium metavanadate
- Molecular formula (if other than submission substance): O3-V.Na
- Molecular weight (if other than submission substance): 121.9
- Smiles notation (if other than submission substance): [V](=O)(=O)[O-].[Na+]
- InChl (if other than submission substance): 1/Na.3O.V/q+1;;;-1;/rNa.O3V/c;1-4(2)3/q+1;-1
- Structural formula attached as image file (if other than submission substance): see Fig. 1
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Panlab (Barcelona, Spain)
- Age at study initiation: No data
- Weight (on supply): 28-30 g
- Fasting period before study: No
- Housing: No data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 23 deg C
- Humidity (%): 40 - 60 %
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
VEHICLE
- Concentration in vehicle: 0, 0.10, 0.20, 0.30 and 0.40 mg/mL - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- In the drinking water for 64 days with concentration adjusted twice weekly on the basis of bodyweight and water consumption
- Frequency of treatment:
- Continuous
- Duration of test:
- 64 days exposure, 4 days mating, 10 days gestation (78 days total)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 20, 40, 80 and 80 mg/kg body weight/day
Basis:
nominal in water
- No. of animals per sex per dose:
- 24 males/group
- Control animals:
- yes
- Details on study design:
- Male mice were exposed in the drinking water for 64 days. Groups were subdivided and 8 animals/group were mated with untreated females and 16 animals/group used for pathology and sperm analysis. Mating/cohabitation was for 4 days with 2 untreated females. Females were killed 10 days following the end of the mating period (i.e. Day 10-14 of gestation).
Groups of males were - Statistics:
- Bartlett's test for homogeneity. If homogeneous ANOVA, if non-homogeneous Kruskal-Wallis. Differences relative to controls examined using either Student's t-test or modified t-test
Results and discussion
Observed effects
Reduced epididymal weight noted at 80 mg/kg/day.
Reduced sperm counts noted at 60 and 80 mg/kg/day.
Reduced fertility noted at 60 and 80 mg/kg/day
Any other information on results incl. tables
No signs of toxicity were observed in any of the treated groups.
Reduced weight gain noted at 80 mg/kg/day, resulting in significantly lower mean terminal bodyweights.
Mean absolute and relative testes weights were comparable in all groups. Mean absolute epididymal weights were significantly lower at 80 mg/kg/day, although relative weight was unaffected by treatment.
The reproductive performance of treated males was significantly reduced at 60 and 80 mg/kg/day, although no dose-response relationship was apparent.
Testicular and/or epididymal sperm counts were significantly reduced at 60 and 80 mg/kg/day. Sperm motility was slightly (but not significantly) reduced at 80 mg/kg/day and the proportion of morphologically abnormal spermatozoa was slightly increased in this group.
No gross or microscopic lesions were observed in the testes and epididymides and epididymal tubular diameter was unaffected by treatment.
Fertility and litter parameters
|
Dose level (mg/kg/day) |
||||
0 |
20 |
40 |
60 |
80 |
|
No. pregnant females |
13/16 |
12/16 |
12/16 |
7/16 |
10/16 |
Pregnant females (%) |
81.3% |
75.0% |
75.0% |
43.8%** |
62.5%** |
No. Implantations |
13.7 |
13.1 |
15.3 |
15.5 |
13.2 |
No. Early resorptions |
0.9 |
0.8 |
1.3 |
0.8 |
1.6 |
No. Late resorptions |
0.0 |
0.5 |
0.0 |
0.3 |
0.0 |
No. Dead foetuses |
0.0 |
0.1 |
0.2 |
0.0 |
0.0 |
No. Live foetuses |
12.8 |
11.7 |
13.8 |
14.4 |
11.6 |
**significantly different to controls (p<0.001)
Organ weights / sperm analysis
|
Dose level (mg/kg/day) |
||||
0 |
20 |
40 |
60 |
80 |
|
Terminal bodyweight (g) |
41.4 |
42.0 |
39.4 |
41.0 |
36.2* |
Left testis (mg) |
126.9 |
127.3 |
136.2 |
162.5 |
121.3 |
Right testis (mg) |
135.1 |
128.2 |
136.7 |
133.4 |
129.2 |
Total testes weight (mg) |
262.1 |
256.1 |
273.0 |
266.0 |
251.0 |
Total testes weight (%) |
0.64 |
0.61 |
0.69 |
0.65 |
0.70 |
Left epididymis (mg) |
47.1 |
49.6 |
49.1 |
46.6 |
41.7* |
Right epididymis (mg) |
48.3 |
51.2 |
49.4 |
48.7 |
42.6* |
Total epididymis weight (mg) |
95.5 |
100.8 |
98.6 |
95.4 |
84.4** |
Total epididymis weight (%) |
0.23 |
0.24 |
0.25 |
0.23 |
0.24 |
Spermatid count (x106/g testis) |
91.8 |
126.3** |
96.2 |
84.5 |
64.7** |
Spermatid count (x106/testis) |
12.3 |
15.9** |
12.6 |
11.3 |
8.4* |
Spermatid count (x106/testis/ g body weight) |
0.30 |
0.38* |
0.32 |
0.28 |
0.20* |
Spermatozoa count (x106/g epididymis) |
687 |
682 |
714 |
388* |
471* |
Spermatozoa count (x106/epididymis) |
33.1 |
34.7 |
35.1 |
18.6* |
19.9** |
Spermatozoa count (x106/epididymis/ g body weight) |
0.80 |
0.83 |
0.88 |
0.45* |
0.55* |
% motile |
28 |
34 |
31 |
28.6 |
17.6 |
% abnormal |
8 |
5 |
7 |
6 |
12 |
Tubular diameter (µm) |
197.4 |
203.3 |
187.7 |
198.2 |
183.5 |
*significantly different to controls (p<0.01); **p<0.001
Applicant's summary and conclusion
- Conclusions:
- The reproductive toxicity of sodium metavanadate has been investigated in male mice by administration in the drinking water at dose levels of 0, 20, 40, 60 or 80 mg/kg/day for 64 days before mating with untreated females. Reproductive performance, organ weights, testicular pathology and sperm parameters were evaluated.
Reduced weight gain was seen in males at the highest dose level. A significantly reduced pregnancy rate was seen at 60 and 80 mg/kg/day with no dose-response relationship apparent. Reduced epididymis weight was observed at 80 mg/kg/day although testis weights were unaffected by treatment. Sperm counts were significantly decreased at 60 and 80 mg/kg/day but sperm motility was not affected. Histopathological examination revealed that the testes and epididymides were normal and contained normal appearing sperm.
These findings suggest that high dose levels of sodium metavanadate may to have an adverse effect on male fertility in mice. - Executive summary:
The reproductive toxicity of sodium metavanadate has been investigated in male mice by administration in the drinking water at dose levels of 0, 20, 40, 60 or 80 mg/kg/day for 64 days before mating with untreated females. Reproductive performance, organ weights, testicular pathology and sperm parameters were evaluated.
Reduced weight gain was seen in males at the highest dose level. A significantly reduced pregnancy rate was seen at 60 and 80 mg/kg/day with no dose-response relationship apparent. Reduced epididymis weight was observed at 80 mg/kg/day although testis weights were unaffected by treatment. Sperm counts were significantly decreased at 60 and 80 mg/kg/day but sperm motility was not affected. Histopathological examination revealed that the testes and epididymides were normal and contained normal appearing sperm.
These findings suggest that high dose levels of sodium metavanadate may to have an adverse effect on male fertility in mice.
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