Registration Dossier
Registration Dossier
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EC number: 453-480-2 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 October 2003 to 30 October 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20.4 °C
- pH:
- >= 8 - <= 8.1
- Details on results:
- Test substance was stirred with double distilled water for 6 days at 20.4 +/- 0.7°C (nominal concentration was 12 mg/l). The concentration of HATCOL 5127 in the supernatant after two, three and four successive times of centrifugation (3500 g, 5 min. and 20°C) was 86.7, 138 and 107 µg/l, respectively. The measured pH was after two, three and four successive times of centrifugation 8.1, 8.0 and 8.0, respectively.
Due to the experience with similar test substances (e.g. Hatcol 3365; see NOTOX project 382319) it was decided not to perform a main study. Taking all results into account, the water solubility of Hatcol 5127 at 20.4+/- 0.7°C is reported as < 0.14x10-3 g/l
Based on NOTOX experience with similar test substances, a more accurate determination of the water solubility for this kind of extremely apolar test substances (log Pow ≥ 7, see NOTOX project 388068 "Determination of the partition coefficient (N-octano1/water) of Hatcol 5127)" is impossible. - Conclusions:
- A preliminary test was used to determine the water solubility of HATCOL 5127 which was based on the following guidelines:
OECD guideline for testing of chemicals no. 105 "Water Solubility", Adopted July 27, 1995.
EEC Direction 92/69 EEC, Part A, Methods for determination of physico-chemical properties, A.6: "Water solubility". EEC Publication No. L383, December 1992.
The water solubility of HATCOL 5127 at 20.4 +/- 0.7˚C is < 0.14 x 10-3 g/l, the pH was between 8.0-8.1
Reference
Description of key information
A preliminary test was used to determine the water solubility of HATCOL 5127 which was based on the following guidelines:
OECD guideline for testing of chemicals no. 105 "Water Solubility", Adopted July 27, 1995.
EEC Direction 92/69 EEC, Part A, Methods for determination of physico-chemical properties, A.6: "Water solubility". EEC Publication No. L383, December 1992.
The water solubility of HATCOL 5127 at 20.4 +/- 0.7˚C is < 0.14 x 10-3 g/l, the pH was between 8.0-8.1
Key value for chemical safety assessment
- Water solubility:
- 0.14 mg/L
- at the temperature of:
- 20.4 °C
Additional information
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