Registration Dossier
Registration Dossier
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EC number: 457-940-3 | CAS number: 183065-68-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July/August 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD and GLP guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.4
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-bromo-2,6-difluorobenzoic acid
- EC Number:
- 457-940-3
- EC Name:
- 4-bromo-2,6-difluorobenzoic acid
- Cas Number:
- 183065-68-1
- Molecular formula:
- Hill formula: C7H3BrF2O2 CAS formula: C7H3BrF2O2
- IUPAC Name:
- 4-bromo-2,6-difluorobenzoic acid
Constituent 1
Test animals
- Species:
- other: rbt, Crl:KBL(NZW)BR
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Wasser
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 6 days
- Other effects:
- Keine
"ENGLISH"
None
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Executive summary:
The skin irritation potential of 4-Bromo-2,6-difluorobenzoic acid was tested according to OECD 404. 4-Bromo-2,6-difluorobenzoic acid was shown to cause no irritation (mean score of 0 for erythema and edema).
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