Registration Dossier
Registration Dossier
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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Mar 1995 - 29 Jun 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
- Details on test material:
- Abbott-87440
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Inc.
- Age at study initiation: 8 to 9 weeks
- Weight at study initiation: 190 to 217g
- Housing: Individual stainless steel hanging cages
- Diet :Certified Rodent Chow, ad libitum
- Water: ad libitum
- Acclimation period: min 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68° to 70°
- Photoperiod (hrs dark / hrs light): 12hrs/12hrs
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 x 50mm
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): applied to the shaven back of each animal - Duration of exposure:
- 24 hr
- Doses:
- 2g/kgbw
- No. of animals per sex per dose:
- seven male and five female
- Details on study design:
- All rats observed frequently on day of treatment and daily for 13 days for total of 14 days.
All animals weighed prior to dosing and weekly thereafter.
Necropsy of survivors performed: yes, 2 weeks after treatment.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2,000 mg/kg bw; Number of animals: 7; Number of deaths: 0
Female: 2,000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Except for red discharge noted from the nares of most animals on the day of treatment, no overt signs of toxicity or signs of irritation at the topical application site were observed in male or female rats in this study.
- Gross pathology:
- no effect
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose to rats was demonstrated to be >2,000 mg/kg bodyweight
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