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Diss Factsheets
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EC number: 941-187-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD guideline and in compliance with GLP. The original study was reliability 1. Read across to the registered substance is considered scientifically justified and reliabiltiy 2.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Alcohols, C10-16
- EC Number:
- 267-019-6
- EC Name:
- Alcohols, C10-16
- Cas Number:
- 67762-41-8
- IUPAC Name:
- tetradecan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Safol(TM) 23 Alcohol C10-16 alcohols Type B (also known as Compound 33A). Equivalent to Alcohols, C12-13-branched and linear (CAS 740817-83-8).
- Physical state: clear, transparent liquid
- Storage condition of test material: at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Wiga, Germany
- Age at study initiation: 5-6 weeks
- Weight at study initiation: mean bodyweight males 215g, females 151g
- Fasting period before study: overnight
- Housing: a maximum of 5 animals/cage, stainless steel cages fitted with wire screen floor and front
- Diet: standard leboratory rodent diet, ad libitum (except fast and 4 hours after administration of test substance)
- Water: tap water, ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 52-75
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 15 April 1998 To: 12 May 1998
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- undiluted
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.5ml/kg bw
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3M, 3F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were made within 1 hour and within 4 hours after dosing, and subsequently at least once daily throughout the rest of the observation period. The body weight of each animal was recorded immediately before dosing, and of the surviving animals on days 3, 7 and 14 of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: The animals were examined for external changes; the abdomen and the thorax of each animal was then opened and examined for gross pathological changes.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no mortalities.
- Clinical signs:
- Diarrhoea was observed in 1 male and 2 females within 4 hours of dosing. 2 females showed piloerection within 1 hour of dosing while the remaining female showed sluggishness and piloerection within 1 and 4 hours and hunching and blepharospasm within 1 hour. During the remainder of the 14 day observation period none of the animals showed any clinical signs.
- Body weight:
- All animals gained weight normally during the study.
- Gross pathology:
- Unremarkable.
- Other findings:
- SEX-SPECIFIC DIFFERENCES: No difference in mortality females showed more clinical signs immediately after dosing but all normal within 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The rat oral LD50 for Safol(TM) 23 Alcohol C10-16 alcohols Type B (also known as Compound 33A) is >2000 mg/kg. There was no target organ toxicity. Transient signs of intoxication occurred within a few hours of dosing and included diarrhoea, piloerection and lethargy. Findings at gross necropsy were unremarkable.
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