Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-291-6 | CAS number: 56-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
Justification for classification or non-classification
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)