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EC number: 700-740-0 | CAS number: 1103234-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study conducted under GLP conditions and in acc. with OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
- EC Number:
- 700-740-0
- Cas Number:
- 1103234-56-5
- Molecular formula:
- C10H11F2NO4S
- IUPAC Name:
- 2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
- Details on test material:
- -Substance type: organic
-Physical state: solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Details on test solutions:
- Prior to the definitive test a non-GLP range finding test with the nominal
concentrations of 1, 10 and 100 mg/1 was performed.
Since no significant effects were observed in this range finding test only a limit test
with the nominal concentration of 100 mg/1 was performed as a definitive test.
Due to the limited water solubility of the test substance, only the water
accommodated fraction was tested.
This water accommodated fraction was prepared by addition of the respective
amount of an acetonic stock solution to an empty glass vessel. After complete
evaporation of the solvent, the aerated Oaphnia medium (Tables 1 and 2) was
added. The test solution was moderately stirred overnight followed by filtration
(MILLIPORE AP15 glass fibre filter). The resulting water accommodated fraction
was used in the test.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 79.8 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 79.8 mg/L
Applicant's summary and conclusion
- Executive summary:
The median effective concentration (EC50) of SAC-Sulfonamidsaure to Daphnia magna was investigated under static exposure conditions over a period of 48 h. The only applied nominal test concentration was 100 mg/1. 40 individual Daphnia divided into 2 test vessels were exposed to the test substance. Chemical analyses of the test substance concentrations were conducted at the beginning of the test as well as after 24 and 48 h of incubation, respectively. The analyses revealed that the test material was only partly dissolved and that the test substance concentrations were satisfactorily maintained over the whole exposure period. Using the water accommodated fraction of SAC-Sulfonamidsaure no toxic effects (=<10% immobilization) were observed after 24 and 48 h of exposure. No toxic effects were also observed in the control after 24 and 48 h of exposure. Based on these results it can be concluded that the 24 and 48 h EC50 values of SAC-Sulfonamidsaure were >100 mg/1 with respect to the loading rate. Based on the analytically determined concentrations the 24 and 48 h EC50 values were >79.9 and >79.8 mg/1, respectively. The no-observed-effect concentration (NOEC) for 24 and 48 h of incubation was 100 mg/1 with respect to the loading rate. Based on the analytically determined concentrations the 24 and 48 h NOEC were 79.9 and 79.8 mg/1, respectively. 100% immobilization was not detected
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