Registration Dossier
Registration Dossier
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EC number: 236-415-0 | CAS number: 13360-63-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Based on results of a Pseudomonas Growth Inhibition test, the NOEC value of the free amine is considered to be 125 mg/L. Growth inhibiton was >90% at 250 mg/L. No toxicity to microorganisms was seen in several studies up to 2000 mg/L when the pH was adjusted.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 125 mg/L
Additional information
The toxicity of N-ethylbutylamine to microorganisms was examined according to DIN 38412 part 8 (Pseudomonas growth inhibition test). Without pH adjustment no effect was noted up to and including 125 mg test substance/L, whereas almost complete inhibition (93%) was noted at 250 mg/L. When the pH was adjusted, a growth stimulation was noted at 500 mg/L, the highest tested concentration (BASF, 1989).
An increase of the respiration rate was seen after 3 hours when activated sludge was treated with 1000 and 2000 mg/L, respectively, in tests that were conducted according to OECD TG 209 (BASF, 1983, 19899).
The toxicity of the neutral organic was obviously low in both test systems. Though the adjustment of the pH is not reported in the respiration test summaries it is reasonably assume that the pH was adjusted. Thus, toxicity to microorganisms depends largely on the high pH when the free amine comes into contact with bacteria.
Therefore, the NOEC value of the free amine is considered to be 125 mg/L.
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