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Diss Factsheets
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EC number: 449-410-5 | CAS number: 18084-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Oral, subacute 4 weeks (Rat-Wistar, GLP, OECD TG 407): NOAEL = 8 mg/kg bw/day; the findings at 50 mg/kg bw/day (LOAEL) were considered as of minor toxicological relevance; the dose of 200/100 mg/kg bw led to severe organ damage and deaths
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Study duration:
- subacute
- Species:
- rat
Additional information
In a 4 week oral toxicity study on 10 male and 10 female rats per group the daily oral administration of the test substance in doses of 8 and 50 mg/kg bw was well tolerated. The findings (increased sialorrhea; increased incidences of porphyrin deposits in the Harderian gland of male and female animals) in the 50 mg/kg bw dose group were judged as of minor toxicological relevance.
Signs of severe intolerance including deaths were found after 7 days of treatment with 200 mg/kg bw, whereafter the dose was reduced to 100 mg/kg bw. The signs of intolerance were reduced after reduction of dose, however, the animals still showed signs of toxicity such as reduced body weight, changes in blood parameters, atrophy of male sexual organs and changes in the lymphatic system.
Microscopic lesions were noted in the stomach, thymus, spleen, lymph nodes and bone marrow of both sexes and in the male sexual organs.
Severe forestomach lesions were observed in some animals which died or were sacrificed during administration of the high dose which may be caused by local irritation. It is suggested by the author of the report that the other substance related effects are secondary to these lesions and the subsequently degenerating status of the animals.The NOAEL was established in this study with 8 mg/kg bw/day, while the findings at 50 mg/kg bw (LOAEL) were considered as of minor toxicological relevance. The daily dose of 200 mg/kg bw, reduced on day 8 to 100 mg/kg bw, led to severe organ damage and deaths in males and females.
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC or Regulation (EC) No. 1272/2008 (CLP) is recommended as follows:
R48/22 (Harmful: danger of serious damage to health by prolonged exposure if swallowed)
STOT Rep. Exp. 2 (H373: May cause damage to organs through prolonged or repeated exposure.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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