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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
From the results of a Zahn-Wellens test on inherent biodegradability performed according to EU method C.9 (equivalent to OECD 302B; reliability category 2) inoculum toxicity of cyclohexanone oxime can safely be excluded at the initially applied nominal concentration of 656 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 656 mg/L
Additional information
Inherent biodegradability of the test item cyclohecanone oxime was assessed in a Zahn-Wellens test on inherent biodegradability performed according to EU method C.9 (equivalent to OECD 302B; reliability category 2). An initial test item concentration of nominal 656 mg/L was applied, corresponding to 400 mg/L DOC (nominal). Actual test item concentration was slightly higher deduced from the measured DOC of 421 mg/L (value from inoculum blank substracted). Non-adapted sludge from a STP receiving industrial and domestic sewage was applied with a final concentration of solids of 0.5 g/L. The first DOC determination was carried out after 3 hours to account for elimination due to adsorption. This was determined to be negligible (2.7%). Adaption phase was very short, as already between day 1 and 3 degradation phase began and at day 3 already 50.2% of the test item were degraded. The final degradation level at the end of the test amounts to 96.5%. All reported degradation values are exclusive of elimination, i.e. the DOC determined after 3 hours was taken as the reference value according to the EU-guideline. Conclusions:
- Cyclohexanone oxime is inherently biodegradable, fulfilling specific criteria (≥70 % mineralisation (DOC removal) within 7 d; log phase no longer than 3d; removal before degradation occurs was below 15%, namely 2.7% and inoculum was not pre-adapted).
- Elimination due to adsorption was negligible (2.7% within 3 hours).
- Inoculum toxicity can safely be excluded at the initial nominal concentration of cyclohexanone oxime of 656 mg/L. The Zahn-Wellens test can therefore be used as key study for hazard assessment for STP microorganisms. In line with REACH guidance on Information Requirements and Chemical Safety Assessment part R.10 the initial nominal concentration of cyclohexanone oxime of 656 mg/L will be regarded as a NOEC STP-microorganisms.
This is supported by a short-term test on activated sludge respiration inhibition (reliability category 3 due to short incubation period) according to ISO 8192 (draft 1984) and similar to OECD 208. The following effect concentration for the test item cyclohexanone oxime (highest tested concentration: 3598 mg/L) were determined in this test:
Highest tested concentration with less than 20% respiration inhibition within 30 min.: 1199 mg/L
EC20 (30 min): 1500 mg/L
EC50 (30 min): 3000 mg/L
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