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EC number: 203-526-0 | CAS number: 107-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15. Oct 1987 - 29. Oct 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
Test material
- Reference substance name:
- Isopentylamine
- EC Number:
- 203-526-0
- EC Name:
- Isopentylamine
- Cas Number:
- 107-85-7
- Molecular formula:
- C5H13N
- IUPAC Name:
- isopentylamine
- Details on test material:
- - Name of test material (as cited in study report): Isopentylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR. K. THOMAE GMBH, Biberach, Germany
- Weight at study initiation: male: 191 g (mean); female: 189 g (mean).
- Fasting period before study: 16 h
- Housing: 5 animals per cage
- Diet: KLIBA-LABORDIAET 343, Klingentalmuehle AG, Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2.15%, 4.64% or 10%
- Amount of vehicle (if gavage): 10 ml
- Doses:
- 215, 464 or 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of administration, at least once each workday.
- Frequency of weighing: dasy 0, 7 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 341 mg/kg bw
- 95% CL:
- 251 - 460
- Mortality:
- 1000 mg/kg: 1 female died within 1 h. By 24 h all animals were dead.
464 mg/kg: 4 males and females each died within 24 h.
215 mg/kg: 1 female died within 13 days. - Clinical signs:
- 1000 mg/kg: After 30 min up to 1 h the animals showed dyspnea, apathy, abnormal position, staggering, piloerection, cyanosis, poor general state (see details in table in remarks on results).
464 mg/kg: dyspnea, apathy, piloerection, poor general state, staggering, abnormal position, spastic gait, exopthalmus, impaired general state (see details in table in remarks on results). - Body weight:
- see detailed table in remarks on results.
- Gross pathology:
- Animals that died:
General congestion. Stomach/small intestine: mucosa reddened.
In one animal which died 13 days after substance administration cachexia and empty intestines were noted.
Any other information on results incl. tables
Mortality:
Dose (mg/kg ) | Conc. | Gender | 1 h | 24 h | 48 h | day 7 | day 14 | |
1000 | 10 | male | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | |
1000 | 10 | female | 1/5 | 5/5 | 5/5 | 5/5 | 5/5 | |
464 | 4.64 | male | 0/5 | 4/5 | 4/5 | 4/5 | 4/5 | |
464 | 4.64 | female | 0/5 | 4/5 | 4/5 | 4/5 | 4/5 | |
215 | 2.15 | male | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
215 | 2.15 | female | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 |
Weight (g):
Dose (mg/kg) |
Gender | day 0 | day 7 | day 13 | |||
1000 | male | 198 | - | - | |||
1000 | female | 197 | - | - | |||
464 | male | 183 | 163 | 189 | |||
464 | female | 182 | 199 | 208 | |||
215 | male | 191 | 243 | 278 | |||
215 | female | 189 | 211 | 209 |
Clinical signs:
Dose (mg/kg) | 1000 | 464 | |||||
male | female | male | female | ||||
Dyspnea |
30 min - 1 h |
30 min - 1 h |
30 min - 12 d |
30 min - 5 d |
|
|
|
Apathy |
30 min - 1 h |
30 min - 1 h |
30 min - 8 d |
30 min - 5 d |
|
|
|
Abnormal position |
1 h |
1 h |
1 h - 4 h |
1 h - 5 h |
|
|
|
Staggering |
1 h |
1 h |
1 h - 11 d |
1 h - 5 d |
|
|
|
Spastic gait |
- |
- |
1 d - 5 d |
1 d - 4 d |
|
|
|
Piloerection |
30 min - 1 h |
30 min - 1 h |
30 min - 11 d |
30 min - 5 d |
|
|
|
Exopthalmus |
- |
- |
4 h - 5 h |
- |
|
|
|
Cyanosis | - | 1 h | - | - | |||
Impaired general state | - | - | 11 d | - | |||
Poor general state | 30 min - 1 h | 30 min - 1 h | 30 min - 8 d | 30 min - 5 d |
min: minutes
h: hour
d: day
There is indication that the test substance causes local irritation to exposed tissue.
Harmful if swallowed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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