Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 256 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Oral LD50 value in rat of the substance is reported to be 256 mg/kg bw . 3 -Chloroaniline is therefore classified Toxic if swallowed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 256 mg/kg bw
- Quality of whole database:
- Test method not reported.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 550 mg/m³ air
- Based on:
- not specified
- Exp. duration:
- 4 h
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value for inhalation route in mouse of the substance is reported to be 550 mg/m^3 (0.55 mg/l) .
Reference
Lungs, thorax or respiration: cyanosis
Vehavioral: convulsions or effect on sezure threshold
Sense organs and special senses (eye): corneal damage
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 550 mg/m³
- Quality of whole database:
- Test method not reported.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 250 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 value in rat of the substance is reported to be 250 mg/kg . 3-Chloroaniline is therefore classified Toxic in contact with skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 250 mg/kg bw
- Quality of whole database:
- Test method not reported.
Additional information
The preferred test species for evaluation of acute toxicity by the oral route is the rat.
Justification for selection of acute toxicity – inhalation endpoint
More accurate data
Justification for selection of acute toxicity – dermal endpoint
The preferred test species for evaluation of acute dermal toxicity is the rat or the rabbit.
Justification for classification or non-classification
On the basis of the available data 3-Chloroaniline is classified Toxic if swallowed, in contact with skin and if inhaled.
The Chloroanilines have a CLP harmonized classification (Annex VI, Table 3.1, Index no.612-010-00-8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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