Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 400-100-8 | CAS number: 84057-97-6 BLEU N-RM 2114; BLEU NYLOSAN N-BLN; BLUE N-RM 2114; NYLOSAN BLAU N-BLN; NYLOSAN BLEU N-BLN; NYLOSAN BLUE N-BLN
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- other: no details in SNIF file
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only data summary seen from SNIF docs
Data source
Reference
- Reference Type:
- other: ECHA
- Title:
- Unnamed
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- EC Number:
- 400-100-8
- EC Name:
- Sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- Cas Number:
- 84057-97-6
- Molecular formula:
- C28H22N3NaO7S2
- IUPAC Name:
- sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- Details on test material:
- Not defined in record seen - SNIF
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1000 mg/kg
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Blue colouration of skin
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Blue colouration of skin
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 1 000 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Data obtained through ECHA Inquiry under the 12 year rule.
- Executive summary:
Data obtained through ECHA Inquiry under the 12 year rule.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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