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EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG
- Principles of method if other than guideline:
- Five male and 5 female Wistar rats were occlusively applied 1000 or 2000 mg m-chloroaniline/kg bw. The test substance was applied on gauze covering about 10% of the body surface and caped with aluminium foil. After 24 hours the test substance was remouved with lukewarm water. The animals were observed for mortality, clinical signs and body weight gain during a post-observation period of 14 days. a pathological examination was performed on all animals which died during the observation period or were sacrificed at the end of the study period.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- CAS no.: 108-42-9
purity: 99.5%
molecular weight. 127.6 g/mol
appearance: weak yellow liquid
density: 1.21 g/m³
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Duration of exposure:
- 24 hours
- Doses:
- 1000 or 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals/dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Signs of intoxicition at a dose of 2000 mg/kg bw were cyanosis and sedation on male and female rats. A single female rats showed at a dose of 1000 mg/kg bw cyanosis, gaunt flanks and a bad general condition. All other animals revealed no symptoms at a dose of 1000 mg/kg bw.
Pathological signs of the deceased animals at doses of 2000 mg/kg bw were changes of the gastrointestinal tract, brownish discoloured lungs and the urinary bladder was filled plump with liquid on males and one female. The gastrointestinal tract was partly black discoloured on 2 females and one female showed a clay-coloured liver. The animals which died during the post-observation period were cyanotic. All animals sacrificed at the end of the study revealed no pathological signs.
The LD50 is > 1000 and < 2000 mg/kg bw for female rats and ca. 2000 mg/kg bw for male rats.
Applicant's summary and conclusion
- Executive summary:
Five male and 5 female Wistar rats were occlusively applied 1000 or 2000 mg m-chloroaniline/kg bw. The test substance was applied on gauze covering about 10% of the body surface and caped with aluminium foil. After 24 hours the test substance was remouved with lukewarm water. The animals were observed for mortality, clinical signs and body weight gain during a post-observation period of 14 days. A pathological examination was performed on all animals which died during the observation period or were sacrificed at the end of the study period.
Signs of intoxicition at a dose of 2000 mg/kg bw were cyanosis and sedation on male and female rats. A single female rats showed at a dose of 1000 mg/kg bw cyanosis, gaunt flanks and a bad general condition. All other animals revealed no symptoms at a dose of 1000 mg/kg bw.
The LD50 is > 1000 and < 2000 mg/kg bw for female rats and ca. 2000 mg/kg bw for male rats.
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