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Diss Factsheets
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EC number: 217-443-2 | CAS number: 1852-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsitable test system and significant methodological deficiencies (comparable to guideline study OECD 403 - Annex (1981), but solid substance, concentration in the air not quantifiable, only 7 days observation period)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- Inhalation Hazard Test
- Principles of method if other than guideline:
- BASF-TEST: It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (usually 20°C). Young adult laboratory rats were purchased from breeder. Usually the source and strain of animals were not documented. Several groups of usually 3 rats per sex were sequentially exposed to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted disc in a glass cylinder for different time periods. The exposure time not causing lethality was usually tested twice. No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of the test substance weight loss during exposure. Group-wise documentation of clinical signs was performed over the 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- other: Inhalation Hazard Test
Test material
- Reference substance name:
- Propyleneurea
- IUPAC Name:
- Propyleneurea
- Details on test material:
- - Name of test material (as cited in study report): Propyleneurea
- Physical state: solid
- Purity: 97%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean body weight at study initiation:
IHT 20°C experiment 1: group weight 1055 g (6 animals)
IHT 20°C experiment 2: group weight 1157 g (6 animals)
IHT 100°C experiment 1: group weight 1237 g (6 animals)
IHT 100°C experiment 2: group weight 1112 g (6 animals)
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- IHT 20°C experiment 1 and 2: nominal concentration in the air 1.07 mg/L
IHT 100°C experiment 1 and 2: nominal concentration in the air 1.40 mg/L - No. of animals per sex per dose:
- 3 (in total 6 males and 6 females for IHT at 20°C and 6 males and 6 females for IHT at 100°C)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- The animals were examined for mortality and clinical signs of toxicity
- Frequency of observations: several times at the application day and thereafter once each working day
- Body weights were recorded at the beginning and the end of the study
- Necropsy of survivors and animals which died performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Exp. duration:
- 8 h
- Remarks on result:
- other: 20°C; no mortality
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Exp. duration:
- 8 h
- Remarks on result:
- other: 100°C; no mortality
- Mortality:
- No mortality
- Clinical signs:
- other: 20°C: no clinical signs 100°C: flight attempts at the beginning of exposure; after approx. 4 h slight irritation of mucous membranes
- Body weight:
- - Mean body weight at the end of the study:
IHT 20°C experiment 1: group weight 1241 g
IHT 20°C experiment 2: group weight 1298 g
IHT 100°C experiment 1: group weight 1407 g
IHT 100°C experiment 2: group weight not determined - Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
- Conclusions:
- No mortalities were observed. However, it is very likely that there was no/nearly no TS in the air.
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