Registration Dossier
Registration Dossier
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EC number: 215-951-9 | CAS number: 1459-93-4
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
Description of key information
According to Regulation (EC) No.1907/2006, Annexes IX and X, Column 2, further testing for ultimate biodegradation in surface water or sediment shall be
proposed if the chemical safety assessment according to Annex 1 indicates the need to investigate further the degradation of the substance or its degradation products; additional testing need not be proposed if the substance is readily biodegradable, or if direct and indirect exposure to the relevant environmental
compartment is unlikely. The substance has been shown to be readily biodegradable. The chemical safety assessment did not indicate the need to further
investigate the degradation of the substance; the risk characterisation ratios for surface water sediment are below one. Therefore, in accordance with Annex I, the risks are considered controlled, and further degradation testing in surface water and sediment is waived.
Key value for chemical safety assessment
Additional information
Although additional testing on the biodegradability of the dimethyl isophthalate was not required, the scientific literature provides information on the degradation of the substance in sediments under anaerobic conditions. Complete degradation of the substance by bacterial strains isoltaed from mangrove sediments was achieved by sequential degradation mediated by Klebsiella oxytoca Sc and Methylobacterium mesophilicum Sr. Primary degradation of the substance was demonstrated under sulphate-reducing conditions in a sediment microcosm study, although complete mineralisation was not achieved (65% degradation of dimethyl isophthalate was reported after two months).
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