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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-963-7 | CAS number: 112-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: sediment simulation testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- other: Expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A weight of evidence approach was used in the expert assessment to address simulation testing on
ultimate degradation in surface water. - GLP compliance:
- no
- Inoculum or test system:
- other: Expert assessment
- Remarks on result:
- other: Expert assessment
- Transformation products:
- not measured
- Conclusions:
- Based on the fact that bis(2-ethoxyethyl) ether is not readily biodegradable and data is not available to reach a conclusion on its persistence, a worst case scenario approach has been followed to classify the substance as Persistent in section 2.3 PBT assessment.
We conclude that a simulation test in surface water is not expected to reveal any new
findings, therefore, testing is considered scientifically not necessary. - Executive summary:
A weight of evidence approach was used to address simulation testing on ultimate degradation in surface water of bis(2-ethoxyethyl) ether.
An assessment of the degradability potential of bis(2-ethoxyethyl) ether has been undertaken in a GLP complaint screening test conducted according to the OECD TG 301F. The substance was not considered to be readily biodegradable under the conditions of this test.
Degradation is an important endpoint to fulfil regulatory needs for persistence assessment. As such, a worst case scenario approach has been followed to classify the substance as Persistent in section 2.3 PBT assessment.
None of the ecotoxicological studies identified a need for classification and the substance is not considered bioaccumulative based on Log Kow <=4.5 (log P for the substance was determined to be 0.39 at 25°C) or toxic based on available data.Therefore, we concluded that a simulation test in surface water is not expected to reveal any new findings, therefore, testing is considered scientifically not necessary.
Referenceopen allclose all
Description of key information
In accordance with Column 2 adaptation statement of REACH Annex IX, sediment simulation testing, information requirement 9.2.1.4 does not need to be conducted as direct and indirect exposure to sediment is unlikely. The test substance entering the water is not likely to sorb onto suspended solids and sediment based upon the calculated Kow (CSR section 1.3 Physico-Chemical Properties), mitigating exposure to sediment. See supporting sorption data (CSR section 4.2.1 Adsorption/desorption) and exposure assessment information (CSR Chapter 9).
Based on the fact that bis(2-ethoxyethyl) ether is not readily biodegradable and data is not available to reach a conclusion on its persistence, a worst case scenario approach has been followed to classify the substance as Persistent in section 2.3 PBT assessment. We concluded that a simulation test in surface water is not expected to reveal any new findings, therefore, testing is considered scientifically not necessary.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.