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EC number: 203-897-9 | CAS number: 111-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline comparable to OECD 402
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution à l'étude toxicologique de l'alcool n-heptylique primaire,
- Author:
- R. Truhaut
- Year:
- 1 974
- Bibliographic source:
- Archive des maladies professionelles, de medecine du travail. T35, No 4-5, Avril-Mai (p 501-509)
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Draize et al., J pharmacol exp thera, 19477, 82, 377-390.
- GLP compliance:
- no
- Test type:
- other: Draize et al 1944
- Limit test:
- no
Test material
- Reference substance name:
- Heptan-1-ol
- EC Number:
- 203-897-9
- EC Name:
- Heptan-1-ol
- Cas Number:
- 111-70-6
- Molecular formula:
- C7H16O
- IUPAC Name:
- heptan-1-ol
- Details on test material:
- Name: n-heptanol-1
Cas No. 111-70-6
Purity>97%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits were shaved on both the left and right side and also on the back, The skin exposure surface was therefore estimated between 200 cm2 to 350-400 cm2.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- exposure surface= 250 to 350-400 cm2.
- Duration of exposure:
- 2 weeks
- Doses:
- 40 ml (1.3 g/kg) and 50 ml (2.7 g/kg)
- No. of animals per sex per dose:
- 6 animals/dose
- Control animals:
- no
- Details on study design:
- 50 ml of test item was administered on the skin surface. Animals were shaved on the back and the left and right sides. The dose-levels of 25 ml (20.5 g) , 40 ml ( 32.8g) and 50 ml (41.0g) were administrated by the cutaneous route. Half of the animals were sacrificed 2 weeks after the fisrt exposure and and the other half 6 weeks after. Major organs were sampled for histopathlogical examination.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 25 ml (20.5 g equivalent 7.32 g/kg): no absorption, no mortality
40 ml(32.8g equivalent 11.7 g/kg): 1.3 g/kg interna dose: 2/6 dead animals
50 ml (41g equivalent 14.6 g/kg) : 2.7 g/kg internal dose: 4/6 dead animals. - Clinical signs:
- other: At the absorbed dose-levels of 1.3 and 2.7 g/kg,tThe skin presented severe escars and sometimes suppurative lesions.
- Gross pathology:
- The results from histopathological examination revealed no alteration of the lung, the heart, liver, kidney, testes, pancreas and spleen. The brain presented spongiosis which was more severe in animals after 6 weeks exposure. The skin presented severe lesions of the derm with deep inflamatory infiltation.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The LD50 of n-heptanol 1 is higher than 2000 mg/kg
- Executive summary:
The acute dermal toxicity of n-heptanol was evaluated in rabbits according to a comparable draize method. The test item was applied to the skin of rabbits (6 animals/dose) at the dose-levels of 20.5, 32.8 and 41.0 g/ animal for 24 hours. Animals were then observed during 14 days for mortality, clinical signs, effects on body weight. Half of the rats were necropsied after 2 weeks and the other half after 6 weeks. 2/6 animals died at the dose-level of 32.8 g/animal (approx 11.7 g/kg) and 4/6 animals died at 2.7 g/animal (equivalent 14.6 g/kg). Lesions of the skin (caustic) and the brain were recorded at histopathological examination.
The LD 50 by dermal route was higher than 2 g/kg.
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