Registration Dossier
Registration Dossier
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Reaction mass of (1R,4S,4aR,8R,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8S,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1R,4S,4aR,8S,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8R,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one
EC number: 700-770-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
in vitro transcutaneous electrical resistance assay (TER, screening level study for skin corrosivity): negative
in vitro rabbit enucleated eye test (REET, screening level study for eye irritation): negative
in vivo rabbit eye irritation study (screening level study): mild irritant (class 4 on a 1-8 scale)
Key value for chemical safety assessment
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Available information:
in vitro transcutaneous electrical resistance assay (TER, screening level study for skin corrosivity): negativein vitro rabbit enucleated eye test (REET, screening level study for eye irritation): negative
in vivo rabbit eye irritation study (OECD 405, non-GLP, screening level): mild irritant (class 4 on a 1-8 scale)
Only a screening level study is available for skin corrosion/irritation. The result given above provides useful information about the corresponding properties of the substance. However the reliability, relevance and adequacy of the data are considered as limited and an overall reliability rating of 3 (= not reliable, according to the scoring system of Klimisch et al.) has been assigned. As a consequence, these data are not adequate for risk assessment and classification and labelling purposes.
A screening level in vitro study is available for eye irritation/corrosion. The result given above provides useful information about the corresponding properties of the substance. However the reliability, relevance and adequacy of the data are considered as limited and an overall reliability rating of 3 (= not reliable, according to the scoring system of Klimisch et al.) has been assigned. As a consequence, these data alone are not adequate for risk assessment and classification and labelling purposes.
In addition an in vivo study for eye irritation is available (OECD 405 with deviations, non-GLP). Its results are reliable, relevant and adequate for risk assessment and classification.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the available information the substance does not meet the criteria for classification for "skin corrosion/irritation" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.2.2; reason for non-classification: inconclusive.
Based on the available information the substance does not meet the criteria for classification for "serious eye damage/eye irritation" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.2.2; reason for non-classification: conclusive but not sufficient for classification.
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