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EC number: 248-652-7 | CAS number: 27774-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Acceptable, well-documented publication which meets basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of vanadium compounds in rats and mice
- Author:
- Llobet, J. M. & Domingo, J. L.
- Year:
- 1 984
- Bibliographic source:
- Toxicology Letters, 23: 227 - 231
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981-05-12
- Deviations:
- yes
- Remarks:
- males only; body weight measurements and gross pathology not conducted
- Principles of method if other than guideline:
- Groups of 10 male Sprague-Dawley rats were given 296, 395, 500, 650, and 845 mg/kg of vanadyl sulfate pentahydrate (VOSO4 * 5H20) in 10 mM Tris-HCl-NaCl buffer (pH 7.4) by gavage. A control group receiving only the vehicle was also used during the study. The animals were observed for mortality and clinical signs during a 14 day observation period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vanadium oxide sulphate pentahydrate
- Cas Number:
- 12439-96-2
- Molecular formula:
- VOSO4 x 5 H2O
- IUPAC Name:
- Vanadium oxide sulphate pentahydrate
- Reference substance name:
- Vanadium oxide sulphate
- EC Number:
- 248-652-7
- EC Name:
- Vanadium oxide sulphate
- Cas Number:
- 27774-13-6
- Molecular formula:
- VOSO4
- IUPAC Name:
- oxovanadium(2+) sulfate
- Reference substance name:
- 12439-96-2
- Cas Number:
- 12439-96-2
- IUPAC Name:
- 12439-96-2
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): Vanadyl sulphate pentahydrate (from Merck (Darmstadt, FRG))
- Molecular formula (if other than submission substance): VOSO4 x 5H2O
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Biocentre (Barcelona, Spain)
- Weight at study initiation: 200 - 250 g
- Diet (ad libitum): Panlab diet
- Water (ad libitum): water
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tris-HCl-NaCl buffer
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
Solution concentrations were adjusted so that a 250 g rat received 1 mL.
DOSAGE PREPARATION:
The test material was dissolved in 10 mM Tris-HCl-NaCl buffer (pH 7.4)
To calculate the LD50 values, a preceding screening with small groups of two or three animals was carried out. - Doses:
- 296, 395, 500, 650, and 845 mg/kg
- No. of animals per sex per dose:
- 10 males
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The LD50 values were calculated according to the Litchfield and Wicoxon method.*
*Reference:
J.T. Kitchfield and F. Wilcoxon, A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther., 96 (1949) 99 - 113
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 448 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 412.2 - <= 486.9
- Remarks on result:
- other: Dose level equivalent to 288.5 mg/kg bw of vanadium oxide sulfate (calculated from the data given in the publication); Dose level equivalent to 90.3 mg/kg bw vanadium (83.1 - 98.1; calculated)
- Mortality:
- The following relation between dosage and mortality in rats was seen (alive/tested):
296 mg/kg: 10/10
395 mg/kg: 6/10
500 mg/kg: 4/10
650 mg/kg: 3/10
845 mg/kg: 0/10
The majority of deaths were observed within the first 48 hours. Few deaths occurred between the second and the seventh days. No death occurred after 7 days. - Clinical signs:
- other: The highest dosage of the vanadium compound caused intense diarrhoea, irregular respiration, increased cardiac rhythm and ataxia. The most noticeable physical signs observed were: decreased locomotor activity, paralysis of the hind legs and decreased sens
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 (male rats): 448 mg/kg bw (vanadium oxide sulfate pentahydrate)
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is classified as Category 4.
LD50 (male rats) = 288.5 mg/kg (vanadium oxide sulfate)(calculate from data of the pentahydrate)
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is classified as Category 3.
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