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EC number: 500-687-1 | CAS number: 162303-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
As tetra-n-butyl titanate, polymer with water hydrolyses rapidly when in contact with water or moisture the bioaccumulation potential is related to the main degradation products, not the substance itself.
The key information of the hazardous degradation product (n-butanol):
Rapid absorption, metabolism and excretion of n-butanol were observed after oral and inhalation routes of administration. n-Butanol was excreted mainly as carbon dioxide in exhaled air. Minority of n-butanol is excreted as oxidized metabolites predominantly in urine.
Dermal absorption of n-butanol through rat skin is poor. Metabolism and excretion show no differences compared to the oral route.
The key information of the non-hazardous degradation product:
As titanium dioxide is not soluble and is eliminated mainly unabsorbed this substance is not expected to have bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No studies on tetra-n-butyl titanate, polymer with water relating to toxicokinetics have been conducted. The assessment of the toxicokinetic behaviour is based on available information on the physical and chemical properties of the substance and the data obtained from the degradation products.
The substance is viscous liquid and hydrolytically unstable. When it comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than n-butanol (CAS 71-36-3) and hydrated titanium dioxide (CAS 13463-67-7). These degradation products from hydrolysis study were determined by using OECD 111 method under Good Laboratory Practice (GLP) (Brekelmans, M. J. C., 2013). The hydrolysis reaction of tetra-n-butyl titanate, polymer with water is rapid; the half-life is less than 2 hours under physiological conditions. Thus, the toxicokinetic behaviour of n-butanol and titanium dioxide (TiO2) instead of the target substance is focused in CSA. As the substance is hydrolyzed, and the hazardous degradation product n-butanol is metabolized and excreted rapidly, the substance is not expected to have bioaccumulation potential.
Toxicokinetics of the hazardous degradation product
In an inhalation study, beagle dogs exposed to 50 ppm (0.15 mg/l) n-butanol over a 6-hour period absorbed approximately 55% of the inhaled vapor (DiVincenzo and Hamilton, 1979). The concentration of n-butanol in the blood was below the detection limit both during and after the exposure.
Majority of n-butanol is rapidly metabolized by alcohol dehydrogenases and aldehyde dehydrogenases to carbon dioxide. In an oral study, CD rats excreted 83.3% of the n-butanol dose (450 mg/kg body mass) as carbon dioxide and 4.4% as glucuronide and sulfate conjugates in the urine. 1% was eliminated in feces and 12 % remained in carcass (DiVincenzo and Hamilton, 1979). Rats dosed at 4.5 or 45 mg/kg exhibited a similar pattern of excretion. In the same publication it was reported that after dermal application of 14C-labeled n-butanol the absorption rate through the skin of dogs was 8.8 µg/min/cm2. In other dermal study, n-butanol was evaluated to absorb poorly following an in vitro dermal exposure (Boman and Maibach, 2000). The absorption during ventilation (i. e., allowing for n-butanol evaporation from the skin) resulted in ≤1% absorption.
Deisinger and English (2001) cited in UNEP (2004) administered intravenous (i. v.) doses of 21 mg/kg of n-butyl acetate, n-butanol, or 2.1 mg/kg n-butyric acid to groups of adult male Sprague-Dawley rats. In addition, they administered an i. v. infusion of approximately 21 mg/kg n-butyric acid over 3 minutes. Blood samples were collected and analyzed for each of the butyl series compounds. n-Butanol exhibited biphasic elimination and approached background levels by 18 minutes.
Overall, n-butanol is rapidly absorbed, metabolized, and excreted in rats. Accumulation of n-butanol or its metabolites is unlikely to occur.
Toxicokinetics of the non-hazardous degradation product
Titanium dioxide is insoluble in water and most ingested titanium is eliminated unabsorbed. In rats, about 95% ingested dose of titanium dioxide is recovered from feces indicating that the most ingested titanium is not absorbed from gastrointestinal tract by blood (Patty, F. 1965). However, in humans detectable amounts of titanium can be found in the blood, brain and parenchymatous organs (Friberg, L. et al.1986). Based on average titanium concentrations found in human urine of about 10 µg/liter, it can be calculated that the absorption is about 3% (WHO, 1982).
After chronic inhalation exposure to titanium dioxide, accumulation of the substance was shown in the lungs. Titanium was also present in the lymph nodes adjacent to the lung (HSDB, 2012). However, quantitative information on absorption through inhalation is lacking. Titanium dioxide released from tetra-n-butyl titanate, polymer with water exists as hydrated form and thus human exposure via inhalation is not relevant.
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