4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline)

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 Jan-28 Jun 1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Also according to GLP

Qualifier:

according to guideline

Guideline:

other: EEC A.7 1984

Principles of method if other than guideline:

Flask-stirring method

GLP compliance:

yes

Medium:

standard fat

Solubility:

796.57 mg/100 g solvent

Temp.:

37 °C

Test substance stable:

yes

Analytical data : fat solubility

Test conditions		Duplicate	Integrated peak area	Mass of solution analysed (g)	Fat solubility
Hours at 37 °C	Temperature stirred for 1 hour (°C)				g/100 g fat solution (S^1)	mg/100 g of fat (S)	Mean result each test mg/100 g fat (S)
3	30	A	161545	0.09984	0.76440	770.29	780.35
3	30	B	172096	0.10361	0.78422	790.42
3	50	A	203006	0.11172	0.85669	864.09	907.34
3	50	B	208622	0.10443	0.94164	0.94164
23	30	A	160737	0.10127	0.74988	755.55	760.61
23	30	B	184030	0.11428	0.75984	765.66
23	50	A	186593	0.10169	0.86570	873.26	885.03
23	50	B	184303	0.09784	0.88882	896.79
68	30	A	170550	0.10762	0.74869	754.34	753.57
68	30	B	179621	0.11348	0.74718	752.80
68	50	A	178091	0.10174	0.82641	833.30	839.56
68	50	B	191766	0.10782	0.83874	845.83

Conclusions:

The fat solubility of the test item at 37 °C was determined to be 796.57 mg /100g fat.

Executive summary:

The fat solubility of the test item was determined according to EC A.7 method in compliance with GLP.  The fat solubility of the test item at 37 °C was determined to be 796.57 mg /100g fat.

Reference 2

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 April 2014-08 May 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Also according to GLP

Qualifier:

according to guideline

Guideline:

other: EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OPPTS 830.7840 (Water solubility)

Deviations:

no

Principles of method if other than guideline:

The Flask method was used for the determination of the solubility in n-octanol.

GLP compliance:

yes

Medium:

n-octanol

Solubility:

1.75 g/L

Temp.:

20 °C

Remarks on result:

other: Mean of the concentrations analysed at t=24, 48 and 72 hours.

Test substance stable:

yes

Details on results:

Concentration analysed after 24, 48 and 72 hours of stirring: 1.79, 1.76 and 1.71 g/L, resp.
The maximum difference (MD) of the concentrations analysed was ≤ 15% (4.1% was calculated).
No test substance was detected in the pretreated sample from the blank n-octanol mixture.

Conclusions:

The n-octanol solubility of the substance at 20°C has been determined as 1.75 g/L.

Executive summary:

The n-octanol solubility of the test item was determined according to EC A.6 method and OECD test guideline 105 in compliance with GLP. Using the flask method, it was determined that the solubility of the test item in n-octanol is 1.75 g/L at 20 °C.

Description of key information

Solubility in standard fat: 796.57 mg/100 g fat at 37 °C
Octanol solubility: 1.75 g/L at 20°C

Key value for chemical safety assessment

Solubility in mg/100g standard fat:

796.57

At the temperature of:

37 °C

Solubility in organic solvents at 20°C:

1.75 g/L

Additional information

The fat solubility of the substance was determined according to EEC Method A.7 (1984). The flask-stirring method was applied. Furthermore, the solubility in octanol was examined using the flask method according to OECD 105 (Oudhoff, 2014). A solubility of 1.75 g/L was determined.