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EC number: 607-997-7 | CAS number: 26776-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-03-08 to 2012-03-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- (2004)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- (2008)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at 0 h and after 120 h. All samples were stabilised with methanol (dilution factor 1:2) within the test container and analysed. All test item containing samples were analysed immediately (within 30 min for pH 7, for technical reasons slightly later for pH 4 and 9).
- Buffers:
- pH 4: 45 mL of 0.1 mol/L NaOH were mixed with 250 mL 0.1 mol/L KH2-Citrate and diluted to 500 mL with double distilled water.
pH 7: 148.15 mL of 0.1 mol/L NaOH were mixed with 250 mL 0.1 mol/L KH2PO4, diluted to 500 mL with double distilled water.
pH 9: 106.5 mL of 0.1 mol/L NaOH were mixed with 250 mL 0.1 mol/L H3BO3 in 0.1 mol/L KCL, diluted to 500 mL with double distilled water - Details on test conditions:
- Stock solution: 100 mg/L in acetonitrile
Co-solvent: Methanol, 10 % (v/v)
Test concentration: 150 µg/L in buffer solution(s)
Control: Sterile buffer solutions (pH value 4, 7 and 9)
Temperature: 50 ± 0.5 °C, checked automatically once in an hour and manually once per working day: minimum 49.7 °C, maximum of 50.3 °C - Duration:
- 120 h
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 124 - <= 133 µg/L
- Number of replicates:
- Duplicates
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- (Sterile buffer solutions, pH 4, 7 and 9)
- Statistical methods:
- average of two determinations
- Preliminary study:
- The test item was found to be stable in the preliminary test at pH 4, 7 and 9 at 50 °C. Initial and final concentrations are reported below.
- Test performance:
- Main test: not required
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Validity criteria fulfilled:
- yes
- Conclusions:
- According to the guideline a half life of > 1 year under environmental conditions can be assumed.
- Executive summary:
The hydrolysis of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane was tested according to OECD TG 111 (2004) and EU Method C.7 (2008). In the preliminary test, less than 10% of the test substance was observed to hydrolyse at 50 °C at pH 4,7 and 9 after 120 hours. Performance of the main test was not required. According to the guideline a half life of > 1 year under environmental conditions can be assumed.
Reference
pH-Value of the Test System (50 °C)
measured at test temperature on day of preparation (before sterilisation)
Intended pH-value |
Measured pH-value at 50 °C |
4.0 ± 0.1 |
4.07 |
7.0 ± 0.1 |
7.02 |
9.0 ± 0.1 |
9.00 |
Hydrolysis Results at pH 4 and 50 °C
Hydrolysis Time [hours] |
Replicate |
Concentration
[µg/L] |
Mean |
Degradation
[%] |
0 |
1 |
126 |
126 |
- |
2 |
126 |
|||
120 |
1 |
109 |
120 |
4.76 |
2 |
131 |
Hydrolysis Results at pH 7 and 50 °C
Hydrolysis Time [hours] |
Replicate |
Concentration
[µg/L] |
Mean |
Degradation
[%] |
0 |
1 |
124 |
124 |
- |
2 |
124 |
|||
120 |
1 |
140 |
139 |
0.00 |
2 |
138 |
Hydrolysis Results at pH 9 and 50 °C
Hydrolysis Time [hours] |
Replicate |
Concentration
[µg/L] |
Mean |
Degradation
[%] |
0 |
1 |
129 |
131 |
- |
2 |
133 |
|||
120 |
1 |
126 |
127 |
3.05 |
2 |
127 |
Description of key information
The hydrolysis of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane was tested according to OECD TG 111 (2004) and EU Method C.7 (2008). In the preliminary test, less than 10% of the test substance was observed to hydrolyse at 50 °C at pH 4,7 and 9 after 120 hours. Performance of the main test was not required. According to the guideline a half life of > 1 year under environmental conditions can be assumed.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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