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EC number: 272-211-8 | CAS number: 68783-88-0 Complex combination obtained by steam distillation of soybean oil followed by condensation of the steam. Contains fatty acids, sterols, aldehydes and ketones.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well documented, meets generally accepted scientific principles and is acceptable for assessment.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The absorption of coconut oil was determined in a 47 wk repeated dose study in rats. At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- Cas Number:
- 67701-28-4
- IUPAC Name:
- Glycerides, C8-18 and C18-unsatd.
- Details on test material:
- - Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Individual screen-bottom cages
- Diet: Normal diet; ad libitum
- Water: Ad libitum
ENVIRONMENTAL CONDITIONS
Air-conditioned animal rooms
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- DIET PREPARATION
- Mixing appropriate amounts with (type of food): 18.5% coconut oil was mixed with diet containing additional 2.5% safflower oil as fat source to insure adequacy of the essential fatty acids. No other fat source was used in diet. - Duration and frequency of treatment / exposure:
- 47 wks; ad libitum in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
18.5%
- No. of animals per sex per dose / concentration:
- 15 animals/sex/group
- Control animals:
- no
- Positive control reference chemical:
- None
- Details on study design:
- No data
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption)
- Tissues and body fluids sampled: Feces
- Details: At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.
- Statistics:
- None
Results and discussion
- Preliminary studies:
- None
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The net fat absorption, calculated from dietary intakes and fecal excretion, was 96%. The absorption of coconut oil can be considered to be similar to this value as 2.5% safflower oil was the only other fat source in diet.
- Details on distribution in tissues:
- Not performed
- Details on excretion:
- Not performed
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: High absorption
Under the conditions of the test, the test substance was highly absorbed after dietary administration in rats. - Executive summary:
The absorption of 'glycerides, C8-18 and C18-unsatd.' (as coconut oil) was determined in a 47 week repeated dose study in rats.
The test substance was included at 18.5% level in diets of 15 wistar rats/sex/group for 47 weeks. Additional 2.5% safflower oil was included to insure adequacy of the essential fatty acids. At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.
The net fat absorption was 96%. The absorption of the test substance can be considered to be similar to this value as 2.5% safflower oil was the only other fat source in diet.
Hence, under the conditions of the test, the test substance was highly absorbed after dietary administration in rats.
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