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EC number: 237-358-4 | CAS number: 13762-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Micronucleus test and erythropoiesis: Effect of cobalt on the induction of micronuclei by mutagens.
- Author:
- Suzuki, Y. et al.
- Year:
- 1 993
- Bibliographic source:
- Environmental and molecular mutagenesis 22: 101-106
Materials and methods
- Principles of method if other than guideline:
- CoCl2*6H2O was administered once by intraperitoneal injection to male mice. The test item was investigated for its ability to induce micronuclei in bone marrow cells.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 7791-13-1
- EC Number:
- 616-574-6
- Cas Number:
- 7791-13-1
- IUPAC Name:
- 7791-13-1
- Reference substance name:
- cobalt(II) dichloride hexahydrate
- IUPAC Name:
- cobalt(II) dichloride hexahydrate
- Details on test material:
- - Name of test material (as cited in study report): cobalt(II)chloride hexahydrate
- Molecular formula (if other than submission substance): CoCl2*6H2O
- Molecular weight (if other than submission substance): 238 g/mol
- Analytical purity: no data
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- other: BALB/c AnNCrj
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Japan
- Age at study initiation: 8 weeks
- Weight at study initiation: 22-27 g
- Diet (e.g. ad libitum): CRF-1 diet supplied by Charles River Japan, ad libitum
- Water (e.g. ad libitum): drinking water; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24 ± 1
- Humidity (%): 50 ± 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: water
- Duration of treatment / exposure:
- one injection
- Frequency of treatment:
- one injection
- Post exposure period:
- 30 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 25, 50, 90 mg/kg bw
Basis:
analytical conc.
- No. of animals per sex per dose:
- 5 male animals per dose
- Control animals:
- yes
- Positive control(s):
- none
Examinations
- Tissues and cell types examined:
- bone marrow cells
- Statistics:
- The data for micronucleus induction were analysed statistically by the Kastenbaum-Bowman method [Kastenbaum and Bowman, 1970]. Data for the P/N ratio were analysed statistically using student´s t-test and one-way layout analysis of variance.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
Any other information on results incl. tables
Treatment with the test item induced a dose-dependent increase in MPCE frequency. The P/N ratio was the lowest at 90 mg/kg bw of CoCl2*6H2O in the in-vivo micronucleus test.
Dose of CoCl2*6H2O [mg/kg bw] |
MPCE frequency [%] |
P/N ratio |
90 |
0.75±0.43** |
0.87±0.19** |
50 |
0.46±0.09** |
1.44±0.44 |
25 |
0.12±0.13 |
2.47±0.17 |
0 |
0.18±0.15 |
1.98±0.32 |
Results show mean ± SD
** P < 0.05 statistically different from the solvent control
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
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