Registration Dossier
Registration Dossier
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EC number: 695-745-7 | CAS number: 1079221-49-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Acute oral toxicity:
Only one data is available in a test inspired from OECD guideline 420, where the only dose tested 500 mg/kg bw produced no mortality in rats. However as the tested dose is lower than the one required in a standard limit test (i.e. 2000 mg/kg bw), the result is considered as insufficient for the purpose of classification and labelling.
An additional data summarized in section 7.5.1 (Repeated dose toxicity: oral) gives more information useful for classification. In this 14-day preliminary toxicity test by oral gavage in rats, 5/5 females and 1/5 male dosed at 1000 mg/kg bw were found dead on study day 2, and 4/5 males were sacrificed on study day 4 due to severe clinical signs. This result shows that a dose of 1000 mg/kg bw can be fatal to rats after one or two exposures at this level.
Taking into account these two acceptable data, we can conclude that the test item should be classified as harmful if swallowed (acute toxicity category 4) according to CLP criteria.
Acute dermal toxicity:
Only one data is available in a test inspired from OECD guideline 402, where the only dose tested 500 mg/kg bw produced no mortality in rats. However as the tested dose is lower than the one required in a standard limit test (i.e. 2000 mg/kg bw), the result is considered as insufficient for the purpose of classification and labelling.
However as the test item is poorly absorbed via dermal route (0.106% systematically available in an in-vitro dermal penetration assay, see section 7.1.2), and no toxicity was observed at 500 mg/kg bw by oral and dermal route, no classification for acute dermal toxicity according to CLP criteria is proposed.
Acute inhalation toxicity:
No data is available.
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