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EC number: 217-752-2 | CAS number: 1948-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
The acute oral toxicity dose (LD50) was considered based on different studies conducted on rats for the test chemical. The LD50 value is between 300-2000 mg/kg bw, for acute oral toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical can be classified for acute oral toxicity class IV.
Acute Inhalation Toxicity:
The acute inhalation toxicity study need not be conducted because exposure to humans via inhalation route is not likely taking into account due to the low vapour pressure of the test chemical, which is reported to be 0.00144 mm Hg. Thus, exposure to inhalable dust, mist and vapour of the chemical is highly unlikely. Therefore this study is considered for waiver.
Acute Dermal toxicity:
The acute dermal toxicity dose (LD50) was considered based on different studies conducted on rats and rabbits for the test chemical. The studies concluded that LD50 value is between 200-1000 mg/kg bw, for acute dermal toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical can be classified for acute dermal toxicity class IV.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Data is from study report
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not available
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Jaguar
- Details on oral exposure:
- No other details available
- Doses:
- 50-3200 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 951 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- 50% mortality observed
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 131 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- 50% mortality observed
- Mortality:
- 50% mortality observed at 951 mg/kg bw and 1131 mg/kg bw
- Clinical signs:
- other: Slight weakness
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- The acute oral median lethal dose (LD50) of test chemical in male and female rat was found to be 951 and 1131 mg/kg of body weight respectively.
- Executive summary:
Acute oral toxicity study of test chemical was conducted on male and female rats at the dose concentration of 951 and 1131 mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weakness were observed. Therefore, LD50 value was considered to be 951 and 1131 mg/kg bw when rats were treated with test chemical via oral route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 951 mg/kg bw
- Quality of whole database:
- K1 level experimental data.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Quality of whole database:
- Waiver
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from study report
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity of test chemical in guinea pig
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- not specified
- Duration of exposure:
- 24 hrs
- Doses:
- 500-1000 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No data available
- Mortality:
- Mortality observed between 700-1000 mg/kg bw dose level
- Clinical signs:
- other: Slight edema,staining and blister like spots. Scattered light eschars,sparse hair and some erythema at 1 wk. Light scars at 2 wks.
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- The acute dermal median lethal dose (LD50) of test chemical in guinea pig was found to be >1000 mg/kg of body weight. Acute dermal toxicity of test chemical indicates that it is likely to exhibit acute toxicity by the dermal route in the Category 4.
- Executive summary:
Acute dermal toxicity study of test chemical was conducted on guinea pigs at the dose concentration of 700 -1000 mg/kg bw. The test chemical was administered via dermal application. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight edema,staining and blister like spots, scattered light eschars,sparse hair, some erythema at 1 wk and Light scars at 2 wks were observed. Therefore, LD50 value was considered to be <1000 mg/kg bw when rats were treated with test chemical via dermal route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
- Quality of whole database:
- K1 level experimental data.
Additional information
Acute oral toxicity:
In different studies, the given test chemical has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats for test chemical. The studies are summarized as below –
1. Acute oral toxicity study of test chemical was conducted on male and female rats at the dose concentration of 951 and 1131 mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weakness were observed. Therefore, LD50 value was considered to be 951 and 1131 mg/kg bw when rats were treated with test chemical via oral route.
2. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 400 -3200 mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weakness and vasodilation were observed. Therefore, LD50 value was considered to be 400 -3200 mg/kg bw when rats were treated with test chemical via oral route.
3.Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 615 (422 -895) mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weakness and prostration were observed. Therefore, LD50 value was considered to be 615 (422 -895) mg/kg bw when rats were treated with test chemical via oral route.
4. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 480 (352 -655) mg/kg bw. The test chemical was administered via oral unspesified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weaknes, prostration and vasodilation were observed. Therefore, LD50 value was considered to be 480 (352 -655) mg/kg bw when rats were treated with test chemical via oral route.
5. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 750 -950 mg/kg bw depending on the presence of food in the intestinal tract. The test chemical was administered via oral intubation route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight weaknes, prostration and vasodilation were observed. Therefore, LD50 value was considered to be 750 -950 mg/kg bw when rats were treated with test chemical via oral route.
6. Acute oral toxicity study of test chemical was conducted on male and female Sprague-Dawley rats at the dose concentration of 700 -1000 mg/kg bw. The test chemical was administered via oral unspecified route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Therefore, LD50 value was considered to be <1000 mg/kg bw when rats were treated with test chemical via oral route.
Thus, based on the above summarized studies on test chemical, it can be concluded that LD50 value is between 200-1000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, the given test chemical can be classified for acute oral toxicity class IV.
Acute Inhalation Toxicity:
The acute inhalation toxicity study need not be conducted because exposure to humans via inhalation route is not likely taking into account due to the low vapour pressure of the test chemical, which is reported to be 0.00144 mm Hg. Thus, exposure to inhalable dust, mist and vapour of the chemical is highly unlikely. Therefore this study is considered for waiver.
Acute Dermal Toxicity:
In study report, the given test chemical has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in-vivo experiments in rodents, i.e. most commonly in rats for test chemical . The study is summarized as below –
1. Acute dermal toxicity study of test chemical was conducted on guinea pigs at the dose concentration of 700 -1000 mg/kg bw. The test chemical was administered via dermal application. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of slight edema, staining and blister like spots, scattered light eschars, sparse hair, some erythema at 1 wk and Light scars at 2 wks were observed. Therefore, LD50 value was considered to be <1000 mg/kg bw when rats were treated with test chemical via dermal route.
Thus, based on the above summarized study on test chemical, it can be concluded that LD50 value is between 200-1000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, the given test chemical can be classified for acute dermal toxicity class IV.Justification for classification or non-classification
Based on the above studies on test chemical, it can be concluded that LD50 value is between 300-2000 mg/kg bw, for acute oral toxicity and between 300-1000 mg/kg bw for acute dermal toxicity. Thus, comparing this value with the criteria of CLP regulation, the given test chemical can be classified for acute oral and acute dermal toxicity class IV. For acute inhalation toxicity wavier was added so, not possible to classify.
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