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EC number: 203-236-4 | CAS number: 104-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May 1961 - 15 Jun 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropyldiethylamine
- EC Number:
- 203-236-4
- EC Name:
- 3-aminopropyldiethylamine
- Cas Number:
- 104-78-9
- Molecular formula:
- C7H18N2
- IUPAC Name:
- (3-aminopropyl)diethylamine
- Details on test material:
- - Name of test material (as cited in study report): Diaethylaminopropylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Meyer-Arend rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 153 g (mean)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 400, 800, 1000, 1250 or 1600 cmm/kg bw (166, 322, 664, 830, 1037.5, 1328 mg/kg bw - conversion in mg/kg is based on density: d=0.83 g/cm3 (BASF AG MSDS)
- No. of animals per sex per dose:
- 166, 322, 644 mg/kg: 2 males, 3 females.
830 mg/kg: 4 females, 6 males.
1037.5 mg/kg: 4 males, 6 females.
1328 mg/kg: 2 males, 3 females. - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 830 mg/kg bw
- Mortality:
- 1328 mg/kg: all animals died within 24 h.
1037.5 mg/kg: 4 females died within 24 h and 1 male within 48 h.
830 mg/kg: 3 males and 1 female died within 24 h. 1 male died within 3 days and 1 male within 6 days.
644 mg/kg: 1 male died on day 7. - Clinical signs:
- other: 1328 mg/kg: staggering, beginning lameness of hind limbs, apathy, abdominal position, accelerated respiration. 1037.5 mg/kg: apathy, ruffled fur. 870 mg/kg: ruffled fur, animals were calmer as usual. 644 mg/kg: calmer as usual.
- Gross pathology:
- 1328 mg/kg: 3x stomach filled with red-yellowish content.
1037.5 mg/kg: 1x stomach filled with red-yellowish content, congested liver.
830 mg/kg: 3x stomach filled with red-yellowish content, 2x congestion of liver, spleen and kidneys. 1x small intestine reddened, diarrhoea. 1x fundus reddened.
644 mg/kg: congestion of the lung, distinct peritonitis.
Sacrificed animals:
644 mg/kg: 1x slight paleness of kidney.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | conc. (%) | 1 h | 24 h | 48 h | day 7 | day 14 |
1328 | 20 | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 |
1037.5 | 10 | 0/10 | 4/10 | 5/10 | 5/10 | 5/10 |
830 | 10 | 0/10 | 4/10 | 4/10 | 6/10 | 6/10 |
644 | 8 | 0/5 | 0/5 | 0/10 | 1/10 | 1/10 |
322 | 8 | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 |
166 | 2 | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 |
There is indication that the test substance causes local irritation to exposed tissues.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Executive summary:
In a study comparable to the OECD Guideline 401, test groups of 5 or 10 rats were treated by single gavage application with an aqueous solution of 3 -aminopropyldiethylamine. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated to be ca. 830 mg/kg on the basis of the observed mortalities.
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