Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-316-1 | CAS number: 1809-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- other: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Justification for Read Across is given in Section 13 of IUCLID
Data source
Reference
- Reference Type:
- publication
- Title:
- Fate of n-Butanol in rats after oral administration and its uptake by dogs after inhalation or skin application
- Author:
- Di Vincenzo GD, Hamilton ML
- Year:
- 1 979
- Bibliographic source:
- Toxicology and applied Pharmacology 48: 317-325
Materials and methods
- Principles of method if other than guideline:
- Dogs were exposed to radioactively labelled test item dermally for 60 minutes. Breath and urine were collected for 8 hours. The dermal absorption and the excretion of the substance were determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Source Chemical 09
- IUPAC Name:
- Source Chemical 09
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 60 min
- Doses:
- 20 µCi n-[1-14C]butanol in carrier
- No. of animals per group:
- 2 males
- Details on study design:
- TEST SITE
- Area of exposure: dog skin
- % coverage: ca. 55.6 cm2
- Time intervals for shavings or clippings: 24 hours before application
TEST MATERIAL
- Amount(s) applied: ca. 15 mL
- Concentration: 20 µCi n-[1-14C]butanol in 15 mL carrier
USE OF RESTRAINERS FOR PREVENTING INGESTION: yes, animals were anaesthetised
Results and discussion
Percutaneous absorption
- Time point:
- 60 min
- Parameter:
- rate
- Absorption:
- ca. 8.8 other: µg/min/cm^2
Any other information on results incl. tables
After 60 min, 29 mg of n-butanol was absorbed through the skin of each dog. The absorption rate was 8.8 µg/min/cm2. For comparison the 8-hr elimination of radioactivity in the breath and urine of dogs dosed intravenously with n-[1-14C]butanol was examined. The results are expressed as a percentage of the administered dose. About 15 % of the dose was eliminated in the breath as 14CO2 and 2.7 % was excreted in the urine. There was no unchanged n-butanol detected in the breath. The 8-hr elimination of radioactivity in the breath and urine averaged about 17 % of the administered dose.
Applicant's summary and conclusion
- Conclusions:
- Absorption: 8.8 µg/min/cm2 (29 mg of test item in 60 minutes)
Excretion: 15 % via breath as radioactively-labelled CO2; 2.7 % via urine; 0 % of unchanged test item via breath - Executive summary:
- The elimination of radioactivity after the application of radioactively-labelled test item to the skin of two male Beagle dogs was examined. The hypothesis was that the metabolic fate and disposition of the test item is identical following either iv or dermal administrations. After 60 min, 29 mg of test item was absorbed dermally. The absorption rate was 8.8 µg/min/cm2. By comparison, the 8-hr elimination of radioactivity in the breath and urine of dogs dosed intravenously with the test item was examined. The results are expressed as a percentage of the administered dose. About 15 % of the dose was eliminated in the breath as 14CO2 and 2.7 % was excreted in the urine. There was no unchanged test item detected in the breath. The 8-hr elimination of radioactivity in the breath and urine averaged about 17 % of the administered dose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.