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Diss Factsheets
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EC number: 203-989-9 | CAS number: 112-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- Tetraethylene glycol (Sample No.; 48-349) was obtained from Union Carbide Corporation, Texas City, Texas.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No additional information available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Yes, other eye
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Since fluorescein is used 24 hours after dosing, the eye is washed at that time. Thus duration is for 24 hours
- Observation period (in vivo):
- Up to 7 days.
- Number of animals or in vitro replicates:
- 3 males and 3 females
- Details on study design:
- Male or female New Zealand White rabbits are dosed with volumes of 0.1 ml. The dose is instilled into the lower conjunctival sac of one eye per animal or is placed directly on the eye. The eyelids are held together for one second. Six eyes are dosed per test volume. The eyes are scored at one hour, approximately 4 hours, one day, 2 days, 3 days and 7 days after dosing. Fluorescein (2%) staining is used to determine corneal injury before dosing and at readings after one day.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Following application of 0.1 ml test material into the eye of rabbits, minor, transient irritation which did not involve the cornea was observed..
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 4 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Score represents mean discharge value. See Table 1 for other conjunctival endpoints examined.
- Irritant / corrosive response data:
- In 6 rabbit eyes, 0.1 ml of sample produced no corneal injury. Iritis developed in all 2 eyes by one hour but did not persist at 4 hours. Minor conjunctival irritation was observed in all 6 eyes. After 24 hours, there was no ocular irritation evident in any rabbit.
- Other effects:
- No additional information available.
Any other information on results incl. tables
Table 1 Primary Eve Irritation-Rabbit
Observation Times, Mean (Range) | ||||||
1 hr | 4 hr | 24 hr | 48 hr | 72 hr | 7 days | |
Cornea - Opacity | 0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0)
|
0.0 (All 0) |
0.0 (All 0) |
- Area |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
Iris - Injury |
0.3 (0 to 1) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
Conjunctivae - Redness |
1.0 (All 1) |
1.0 (All 1) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
- Chemosis |
0.7 (0 to 2) |
0.3 (0 to 1) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
- Discharge |
1.7 (1 to 3) |
1.0 (All 1) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
0.0 (All 0) |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Instillation of 0.1 ml of sample into rabbit eyes produced minor, transient irritation which did not involve the cornea.
- Executive summary:
The eye irritation potential of tetraethylene glycol was examined in rabbits. Instillation of 0.1 ml of sample into rabbit eyes produced minor, transient irritation which did not involve the cornea.
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