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EC number: 689-137-0 | CAS number: 247569-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 July 2013-31 July 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- EC Number:
- 689-137-0
- Cas Number:
- 247569-56-8
- Molecular formula:
- C8 H7 F O4 S
- IUPAC Name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- CAS number: 247569-56-8
Batch: 270002C
Purity: 99.86%
Retest date: 20 February 2014
Storage Conditions: room temperature in the dark
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: Dimethyl formamide
- Concentration / amount:
- 50 %w/w in dimethyl formamide
Challenge
- Concentration / amount:
- 50 %w/w in dimethyl formamide
- No. of animals per dose:
- 1 mouse
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 10, 20 and 50 %w/w in dimethyl formamide
- No. of animals per dose:
- 4 mice per dose
Results and discussion
Any other information on results incl. tables
Preliminary Screening Test
Clinical observations, body weight and mortality data are given in Table 1 and local skin
irritation is given in Table 2. The ear thickness measurements and mean ear thickness changes are
given in Table 3.
No signs of systemic toxicity, visual local skin irritation or irritation indicated by an equal to
or greater than 25% increase in mean ear thickness were noted.
Based on this information the dose levels selected for the main test were 50%, 25% or 10% w/w in
dimethyl formamide.
Main Test
Estimation of the Proliferative Response of Lymph Node Cells
The radioactive disintegrations per minute per lymph node and the stimulation index are given in Table 4.
The Stimulation Index expressed as the mean radioactive incorporation for each treatment group
divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration (% w/w) in Stimulation Index Result
dimethyl formamide
10 1.19 Negative
25 1.88 Negative
50 2.23 Negative
Clinical Observations and Mortality Data
Individual clinical observations and mortality data for test and control animals are given in Table 5.
There were no deaths. No signs of systemic toxicity were noted in the test or control animals
during the test.
Body Weight
Individual body weights and body weight change for test and control animals are given in
Table 6.
Body weight change of the test animals between Day 1 and Day 6 was comparable to that observed in
the corresponding control group animals over the same period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Conclusions:
- 2-Fluoro-5-(methylsulfonyl) benzoic acid (CAS Nr. 247569-56-8) was considered to be a nonsensitizer under the conditions of the test (according to OECD guideline 429).
- Executive summary:
Introduction
A study was performed to assess the skin sensitization potential of the test item in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear.
Methods
Following a preliminary screening test in which no clinical signs of toxicity were noted at a
concentration of 50% w/w, this concentration was selected as the highest dose investigated in the
main test of the Local Lymph Node Assay. Three groups, each of four animals, were treated with 50
microL (25 microL per ear) of the test item as a solution in dimethyl formamide at concentrations of
50%, 25% or 10% w/w. A further group of four animals was treated with dimethyl
formamide alone.
Results
The Stimulation Index expressed as the mean radioactive incorporation for each treatment group
divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration (% w/w) in Stimulation Index Result
dimethyl formamide
10 1.19 Negative
25 1.88 Negative
50 2.23 Negative
Conclusion
2-Fluoro-5-(methylsulfonyl) benzoic acid (CAS Nr. 247569-56-8) was considered to be a non
sensitizer under the conditions of the test (according to OECD guideline 429).
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