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Diss Factsheets
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EC number: 200-655-4 | CAS number: 67-48-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: dermal application, rabbit,
skin of the back and ear, 20h duration and observation after 24h and 8d:
not irritating
Eye irritation: rabbit, 50mm³ of the eye, 1h, 24h and 8d: not irritating
(slight irritation after 1h, completely reversible)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented study result, which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A Choline chloride solution (undiluted) was administered to rabbit skin for 20 hours.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- The substance was administered dermally to rabbit skin (back) for 20 hours.
The substance was administered dermally to rabbit ears for 20 hours. - Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated skin served as a control
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 20 hours
- Observation period:
- 24 hours and 8 days after the application for 20 h
- Number of animals:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: ambiguous slight redness was observed on the back of the animals
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days after application
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: no irritation was found on the ears after 20 hour applications
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- ca. 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: ambiguous slight redness was observed on the back of the animals
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Irritant / corrosive response data:
- ambigous slight redness of the skin was observed after a 20 hours application and a 24 hour / 8 days observation period.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The study was considered to be of high quality (reliability Klimisch 2). The substance did not show a significant irritation after a single dermal application to rabbit skin for 20 h. The substance is not considered to be irritating to the skin.
- Executive summary:
- The skin irritation potential of the test substance was investigated in rabbits (BASF, 1963). The test substance was administered to the back or to the ears for 20 hours and the resulting effects were evaluated. After 24 -hours an ambigous slight reddening of the skin of the back, or for the ears after 24 hours and also after 8 days no changes of the skin of any animal were observed. The test item can be regarded as not irritating to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented study result, which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A Choline chloride solution (undiluted) was administered to rabbit eyes for 20 hours.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- The substance was administered to rabbit eyes for 20 hours.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as a control
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 1 h, 24 h, 8 days
- Observation period (in vivo):
- 1 h, 24 h, 8 days
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- the test item was applied unchanged to an area of 1 * 50 mm³ of the rabbit eye
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- > 0
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: slight reddening was observed after 1 hour
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- actual number of animals not reported
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: individual results not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The study was considered to be of high quality (reliability Klimisch 2). The substance did not show a significant irritation after a single ocular application to the rabbit eye for 20 h. The substance is not considered to be irritating to the eyes.
- Executive summary:
- The eye irritation potential of the test substance was investigated in rabbits (BASF, 1963). The test substance was administered to the rabbit eye and the resulting effects were evaluated. After 1-hours a slight reddening was noted, which was fully reversible as after 24 hours and after 8 days no findings were reported. The test item can be regarded as not irritating to the eye.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of skin irritation / corrosion endpoint:
only study available
Justification for selection of eye irritation endpoint:
only study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.