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Diss Factsheets
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EC number: 221-660-8 | CAS number: 3179-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study meets generally accepted scientific principles, but was not conducted in compliance with GLP. Limited reporting.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted to investigate potential for toxicity following high dermal exposures. Appears to be comparable to OECD 402.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(diethoxymethylsilyl)propylamine
- EC Number:
- 221-660-8
- EC Name:
- 3-(diethoxymethylsilyl)propylamine
- Cas Number:
- 3179-76-8
- Molecular formula:
- C8H21NO2Si
- IUPAC Name:
- (3-aminopropyl)diethoxymethylsilane
- Details on test material:
- - Name of test material (as cited in study report): Gamma-aminopropylmethyldiethoxysilane
- Substance type: Cyclic siloxane
- Physical state: Liquid
- Analytical purity: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: 3-5 months
- Weight at study initiation: Average 2.5 kg
- Fasting period before study: No
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- % coverage: No data
- Type of wrap if used: Vinylite sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4.0 and 2.0 ml/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2.0 and 4.0 ml/kg bw
- No. of animals per sex per dose:
- Four males only
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data, but probably day of dosing then on day 14 (weighing).
- Necropsy of survivors performed: yes
- Other examinations performed: Gross pathology - Statistics:
- Thompson's method for LD50 calculation.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.52 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.86 - <= 3.41
- Remarks on result:
- other: 2293 mg/kg bw based on a relative density of 0.91
- Mortality:
- All of the animals in the 4.0 ml/kg bw group died within four days of exposure. One animal in the 2.0 ml/kg bw group died on day three after exposure.
- Clinical signs:
- other: None reported
- Gross pathology:
- Those that died had lung haemorrhage, liver congestion and pale kidneys.
- Other findings:
- Rabbits that survived 24 hours had erythema, edema and necrosis of the skin.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study with limited information, but which appeared similar to the now deleted OECD 402 (not GLP; reliability score 2) the LD50 for 3-(diethoxymethylsilyl)propylamine was 2.52 ml/kg bw (2293 mg/kg bw based on a relative density of 0.91). Corrosive effects on the skin were apparent.
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