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EC number: 700-503-1 | CAS number: 101238-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, less reporting detail than normally in an OECD 111 study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- other: hydrolysis in stomach acid
- Principles of method if other than guideline:
- The stability towards hydrolysis at pH 1.2 and pH 4 was investigated in an adaption of OECD guideline 111.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2,6,6-tetramethylpiperidin-4-yl dodecanoate
- EC Number:
- 700-503-1
- Cas Number:
- 101238-01-1
- Molecular formula:
- C21 H41 N O2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-yl dodecanoate
- Test material form:
- other: slightly viscous liquid
- Details on test material:
- Expiry date: August 2012
Purity: >94%
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Details on study design:
- Buffer pH 1.2 : 3.73 g KCl and 134.0 mL 1N HCl diluted to 1 L with dionized water
Buffer pH 4: 5.88 g citric acid, 3.49 g NaCl and 20.6 mL 1 N NaOH diluted to 1 L with dionized water
Analytical Method: Capillary gas chromatography: Determination of loss of the parent substance.
Tested linear range: 0.1 mg/L – 100 mg/L
0.444 mg (pH 1.2 A), 0.570 mg (pH 1.2 B and C) or 0.509 mg (pH
4.0 A and B) were dissolved in 500 mL of the respective buffer by sonication for 30 min at RT. 15 mL portions of these solutions were filled up in 20 mL brown glass test tubes, seald with ground-in stoppers and stored at 40 °C (pH 1.2) and 70°C (pH 4.0). After defined time intervals test tubes were cooled down to room temperature and 1.5 mL dichloromethane were added. The mixtures were shaken well and then the organic layer was analyzed.
Test item concentration: 0.66 mg/L - Details on dosing and sampling:
- For pH 1.2 eight time points between 2.5 and 99h were examined.
For pH 4, eight time points between 1.7 and 232 h were examined.
Results and discussion
- Preliminary studies:
- The half-life at pH 1.2 at 40°C was 22.8h (mean of 3 experiments).
No significant hydrolysis ( < 10%) was observed at pH 4 at 70°C during ten days.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
The half-live of the substance at pH 1.2 and 40°C was determined in three independet experiments to be 22.7, 23.6 and 22.2 h, resulting in an average of 22.8h.
At pH 4, less than 10% hydrolysis was observed during 10 days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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