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EC number: 213-268-0 | CAS number: 933-48-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48 h) = 94.1 mg/L (OECD 202, Daphnia magna)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 94.1 mg/L
Additional information
To assess the toxicity of the test substance on aquatic invertebrates the results of two studies are available. The first study, which was identified as key study, was carried out following the procedures of the OECD guideline 202 and GLP. The test was performed in a closed system without headspace. Based on the results of a preliminary test, individuals of Daphnia magna were exposed to the following test concentrations: 12.5, 25.0, 50.0, 100.0 and 200.0 mg/L. The test concentrations were verified by GC-MS analysis at the start and the end of test. The measured concentrations remained within ± 20% of the nominal concentrations throughout the exposure period. Therefore, the effect values were calculated based on the nominal concentrations. The EC50 after 48 h was determined to be 94.1 mg/L.
The second study was performed according to DIN 38412 part 11 using Daphnia magna as test organism as well. However, the study is regarded as not reliable (RL3) due to the following reasons: 1. Only a short summary is available without detailed information about test design (e.g. open or closed system; analytical determinations, conditions, measured or nominal effect concentrations). 2. The test duration was only 24 hours. Consequently, the results of this test were not taken into account for the hazard assessment.
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