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Diss Factsheets
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EC number: 219-741-8 | CAS number: 2517-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- see below
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methoxybutanol
- IUPAC Name:
- 3-methoxybutanol
- Reference substance name:
- 3-methoxybutan-1-ol
- EC Number:
- 219-741-8
- EC Name:
- 3-methoxybutan-1-ol
- Cas Number:
- 2517-43-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 3-methoxybutan-1-ol
- Details on test material:
- No data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Albino mixed race
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- weight: 83g - 109 g
Housing: cage (metal)
Administration / exposure
- Route of administration:
- oral: gavage
- Details on route of administration:
- 10% in drinking water administered via gavage.
- Vehicle:
- water
- Details on oral exposure:
- 1 g /kg be
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- once per day on 14 days within a period of 16 days.
- Frequency of treatment:
- see above
Doses / concentrations
- Dose / conc.:
- 1 000 mg/kg bw/day (actual dose received)
- Control animals:
- not specified
- Details on study design:
- No further details specified.
- Positive control:
- No further details specified.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- not applicable
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, non-treatment-related
- Description (incidence and severity):
- Normal weight increase obsereved.
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- no effects observed
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not examined
- Description (incidence and severity):
- Normal excretion
- Behaviour (functional findings):
- no effects observed
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Other effects:
- no effects observed
Any other information on results incl. tables
No effects were observed during treatment and during the observation period of five days. Animals had normal excretion and a normal increase of weight. The blood analysis showed no pathological observation. The macroscopic and histologic examination of the organs (heart, lung, liver, kidney, and spleen) showed no changes.
Applicant's summary and conclusion
- Conclusions:
- No effects were observed during treatment and during the observation period of five days. Animals had normal excretion and a normal increase of weight. The blood analysis showed no pathological observation. The macroscopic and histologic examination of the organs (heart, lung, liver, kidney, and spleen) showed no changes.
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