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Diss Factsheets
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EC number: 455-790-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9/2/2005-18/4/2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to international guidelines. Methods and results well presented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- The initial and final dissolved oxygen concentrations were below those recommend in the test guidelines. This had no adverse effect level.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.6800 (Modified Activated Sludge, Respiration Inhibition Test for Sparingly Soluble Chemicals)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- - Name of test material (as cited in study report): GASIR1
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Amounts of test material (160, 280, 500, 900 and 1600 mg) were each seperately dispersed in approximately 250 ml of dechlorinated laboratory tap water and subjected to ultrasonication for approximately 30 minutes. Synthetic sewage (16 ml), activated sewage sludge (200 ml) and water were added to a final volume of 500 ml to give the required concentrations.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Preparation of inoculum for exposure: The activated sewage sludge sample was maintained on continuous eration in the laboratory at a temperature of 21°C and was used on the day of collection.
- Initial biomass concentration:4.1g/l
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Remarks on exposure duration:
- After 30minutes an extra aliqout wa sampled
- Post exposure observation period:
- /
Test conditions
- Hardness:
- 100mg/l CaCO3
- Test temperature:
- 21°C (Temperature controlled room)
- pH:
- 8.1-8.2
- Dissolved oxygen:
- /
- Salinity:
- /
- Nominal and measured concentrations:
- Initial range finding test: nominal test concentration: 100 and 1000mg/l
Range finding test: 180, 320, 1800 and 3200mg/l
Definitive test: 320, 560, 1000, 1800, 3200 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel:500 ml conical flask
- Aeration:0.5-1l/min
- Biomass loading rate:200ml
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:tap water dechlorinated by passage through an activate carbon filter and partly softened
- Total organic carbon:1.7 mg C/l
- Metals:
- Pesticides:<0.01μg/l
- Chlorine:0.221mg/l
- Alkalinity:113 mg HCO3/l
- Ca/mg ratio:6.375
- Conductivity:439.164μS/cm
OTHER TEST CONDITIONS
- Adjustment of pH:/
- Photoperiod:/
- Light intensity/:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :/
TEST CONCENTRATIONS
- Range finding study: yes
- Test concentrations: Preliminary: 100-1000mg/l, Second test: 90, 160, 900, 1600mg
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol (Final concentration: 3.2 and 32 mg/l)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 560 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: 13% inhibition compared to control
- Details on results:
- - Effect concentrations exceeding solubility of substance in test medium:The water solubility of Gasir1 was < 1.0E-4 g/l . Given this extremely low value and that no significant effects on respiration was observed in the range-finding tests at 100, 180 and 320 mg/l, it was considered justifiable to conduct the definitive study at a nominal test concentration in excess of the water solubility of the test material.
- % inhibition at concentrations tested:
320 mg/l: 4%
560 mg/l: 13%
1000 mg/l: 20%
1800 mg/l: 27%
3200 mg/l: 29% - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC50 (30min) = 12mg/l; EC50 (3h) = 10mg/l
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect of the test material on the respiration of activated sludge micro-organisms gave a 3-hour EC50 of greater than 3200mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 560mg/l. No verification on the determination of this value was given. An EC10 value of 374 mg/l was calculated based on the presented data and a log-logistic model (TRAP 1.21).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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