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EC number: 404-740-9 | CAS number: 115895-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Reproduction/Developmental Screening study (OECD 421), rat: NOAEL (reproduction) >750 mg/kg bw/day in parental animals. NOAEL systemic toxicity (P, F1) > 750 mg/kg bw/day (males/females)
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 750 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The available information comprises an adequate and reliable study, and is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a reproduction/developmental toxicity screening test performed according to OECD 421, the potential adverse effect of ethyl 3,5-dichloro-4- hexadecyloxycarbonyloxybenzoate (AF-366) on reproduction and developmental parameters in rats was assessed (Flaškárová, 2011).
12 Wistar rats/sex/dose were administered 30, 150 and 750 mg/kg bw/day of the test substance; males for 28 days during the pre-mating and mating periods, and females for up to 56 days during the pre-mating, mating, and gestation period and during lactation until day 4. There were 5 unscheduled cases of mortality in female dose groups; 1/12, 2/12 and 2/12 in the 30, 150 and 750 mg/kg bw/day groups, respectively. The causes of these deaths were not test substance-related. There were no treatment-related clinical signs. In the female mid- and high-dose groups, food consumption was reduced during week 2 of the gestation period. This effect is considered to be incidental as the intake was comparable to the control group the rest of the study period. No treatment-related findings were noted during gross necropsy and histopathological examination. In this study the NOAEL for systemic toxicity is considered to be ≥ 750 mg/kg bw/day for male and female rats, as no effects were noted up to and including the highest dose level.
There was no statistically significant difference in reproductive parameters (measured as fertility rate and gestation index) between the control group and treatment groups. Therefore, the NOAEL for reproduction in males and females is considered to be ≥ 750 mg/kg bw/day, as no effects were observed up to and including the highest dose level.
There were no substance-related effects on offspring viability (measured as live birth index and survival index). No clinical signs of toxicity were observed in the offspring and there were no effects on the body weight. No treatment-related effects were observed up to and including the highest dose level, therefore the NOAEL for developmental effects is considered to be ≥ 750 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
Reproduction/developmental toxicity screening test (OECD 421), rat, gavage: NOAEL developmental (F1) > 750 mg/kg bw/d (males/females), NOAEL (maternal) >750 mg/kg bw/day
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 750 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The available information comprises an adequate and reliable study, and is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a reproduction/developmental toxicity screening study performed according to OECD 421, the potential adverse effect of ethyl 3,5-dichloro-4- hexadecyloxycarbonyloxybenzoate (AF-366) on reproduction and developmental parameters in rats was assessed (Flaškárová, 2011). The offspring was observed for viability and treatment-realated effects until Day 5 postpartum.
There was no statistically significant difference between the control and treatment groups for the live birth index, viability index, number of pups and sex ratio of the pups. No clinical signs of toxicity were observed in the offspring and there were no effects on the body weight. No treatment-related effects were observed up to and including the highest dose level, therefore the NOAEL for developmental effects is considered to be ≥ 750 mg/kg bw/day.
Justification for classification or non-classification
The available data on fertility, reproduction and development do not allow a robust hazard assessment with sufficient confidence for classification according to Regulation (EC) 1272/2008, and therefore, no statement on classification can be made.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.