Registration Dossier
Registration Dossier
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EC number: 815-137-9 | CAS number: 573762-62-6
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 AUG 2022 to 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
- EC Number:
- 815-137-9
- Cas Number:
- 573762-62-6
- Molecular formula:
- C7H4F3N3
- IUPAC Name:
- 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
- Details on test material:
- - Appearence : Slightly yellowish brown fine powder
- CAS Number: 573762-62-6
- Molecular formula: C7H4F3N3
- Molecular weight: 187.12
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22CN32583
- Expiry date: 30 March 2024 (retest date)
- Physical Description: Almost white to yellow powder (determined by Charles River Den Bosch)
- Purity: 100.6%
- Purity correction factor: not required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under storage conditions: not indicated
- Stability under test conditions: not indicated
- Solubility and stability of the test item in the solvent/vehicle: not relevant
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing (e.g. warming, grinding): no treatment
Results and discussion
Boiling point
- Key result
- Atm. press.:
- 1 atm
- Decomposition:
- yes
- Decomp. temp.:
- 300 °C
- Remarks on result:
- other: Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
Any other information on results incl. tables
Preliminary test
From the TGA curve it could be derived that starting at 225°C, the weight of the sample decreased significantly. At 313°C, the sample weight had decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (observed colour: beige). The change of the colour indicated reaction and/or decomposition of the test material.
Main study
From the DSC curve obtained at with Experiment 1 an endothermic effect was observed between 125°C and 175°C. The endothermic effect was most likely obtained due to melting of the test material. After the experiment, a beige molten residue remained in the sample container.
Experiment 2 was performed to investigate the process before reaction and/or decomposition of the test material occurs. From the DSC curve an endothermic effect was observed between 125°C and 175°C. The endothermic effect was most likely obtained due to melting of the test material. Starting from 300°C, a second endothermic effect is observed. This is due to reaction and/or decomposition of the test material. After the experiment, a dark brown molten residue remained in the sample container (observed colour: beige).
Applicant's summary and conclusion
- Conclusions:
- The boiling temperature of JNJ-61232574-AAA (T003630) was tested by DSC.
Reaction and/or decomposition of the test material was observed starting at 300°C. Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
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